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CYP2C9 Antibody (720237) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of Hep G2 (Lane 1), Tissue extracts of (30 µg lysate) Mouse liver (Lane 2), Rat liver (Lane 3), K-562 (Lane 4), HeLa (Lane 5), Jurkat (Lane 6) and Tissue extracts of (30 µg lysate) Mouse small intestine (Lane 7). The blots were probed with Anti-CYP2C9 Polyclonal Antibody (Product # 720237, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution).... View More
Product Details
720237
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptides corresponding to Human CYP2C9 (aa 185-203, 451-468, 84-97)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2633211
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Pig and Horse.
Target Information
CYP2C9 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; Cholesterol 25-hydroxylase; CYPIIC9; cytochrome P-450 S-mephenytoin 4-hydroxylase; Cytochrome P-450MP; Cytochrome P450 2C9; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; cytochrome P450, family 2, subfamily C, polypeptide 9; flavoprotein-linked monooxygenase; MGC149605; MGC88320; microsomal monooxygenase; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
Gene Aliases: CPC9; CYP2C; CYP2C10; CYP2C9; CYPIIC9; P450IIC9
UniProt ID: (Human) P11712
Entrez Gene ID: (Human) 1559
cholesterol 25-hydroxylase activity
monooxygenase activity
iron ion binding
drug binding
arachidonic acid epoxygenase activity
steroid hydroxylase activity
oxidoreductase activity
(S)-limonene 6-monooxygenase activity
(S)-limonene 7-monooxygenase activity
oxygen binding
heme binding
caffeine oxidase activity
(R)-limonene 6-monooxygenase activity
oxidoreductase
oxygenase
metabolite interconversion enzyme
xenobiotic metabolic process
steroid metabolic process
monoterpenoid metabolic process
drug metabolic process
epoxygenase P450 pathway
urea metabolic process
monocarboxylic acid metabolic process
drug catabolic process
exogenous drug catabolic process
cellular amide metabolic process
oxidation-reduction process
oxidative demethylation
omega-hydroxylase P450 pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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