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Product Details
PA5-120976
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 211-490 of human CYP2C9 (NP_000762.2).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914548
Product Specific Information
Positive test controls include: A-549, MCF7, U-937, HepG2, 22Rv1, Raji. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein.
Immunogen sequence: PWIQICNNFS PIIDYFPGTH NKLLKNVAFM KSYILEKVKE HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA VVHEVQRYID LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE FPNPEMFDPH HFLDEGGNFK KSKYFMPFSA GKRICVGEAL AGMELFLFLT SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV
Target Information
CYP2C9 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; Cholesterol 25-hydroxylase; CYPIIC9; cytochrome P-450 S-mephenytoin 4-hydroxylase; Cytochrome P-450MP; Cytochrome P450 2C9; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; cytochrome P450, family 2, subfamily C, polypeptide 9; flavoprotein-linked monooxygenase; MGC149605; MGC88320; microsomal monooxygenase; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
Gene Aliases: CPC9; CYP2C; CYP2C10; CYP2C9; CYPIIC9; P450IIC9
UniProt ID: (Human) P11712
Entrez Gene ID: (Human) 1559
cholesterol 25-hydroxylase activity
monooxygenase activity
iron ion binding
drug binding
arachidonic acid epoxygenase activity
steroid hydroxylase activity
oxidoreductase activity
(S)-limonene 6-monooxygenase activity
(S)-limonene 7-monooxygenase activity
oxygen binding
heme binding
caffeine oxidase activity
(R)-limonene 6-monooxygenase activity
oxidoreductase
oxygenase
metabolite interconversion enzyme
xenobiotic metabolic process
steroid metabolic process
monoterpenoid metabolic process
drug metabolic process
epoxygenase P450 pathway
urea metabolic process
monocarboxylic acid metabolic process
drug catabolic process
exogenous drug catabolic process
cellular amide metabolic process
oxidation-reduction process
oxidative demethylation
omega-hydroxylase P450 pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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