Invitrogen

CYP2R1 Polyclonal Antibody

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CYP2R1 Antibody (PA5-87927) in WB

Western blot analysis of CYP2R1 in extracts of various cell lines. Samples were incubated with CYP2R1 Polyclonal antibody (Product # PA5-87927) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.

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产品信息

PA5-87927

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Mouse, Rat

已发表种属

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 252-501 of human CYP2R1 (NP_0787902)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.58 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2804510

产品详细信息

Immunogen sequence: VVYDFLSRLI EKASVNRKPQ LPQHFVDAYL DEMDQGKNDP SSTFSKENLI FSVGELIIAG TETTTNVLRW AILFMALYPN IQGQVQKEID LIMGPNGKPS WDDKCKMPYT EAVLHEVLRF CNIVPLGIFH ATSEDAVVRG YSIPKGTTVI TNLYSVHFDE KYWRDPEVFH PERFLDSSGY FAKKEALVPF SLGRRHCLGE HLARMEMFLF FTALLQRFHL HFPHELVPDL KPRLGMTLQP QPYLICAERR; Positive Samples: Mouse testis, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein

靶标信息

CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in CYP2R1 gene has been associated with selective 25-hydroxyvitamin D deficiency.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。