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Product Details
PA5-101318
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CYP3A4(Accession P08684), corresponding to amino acid residues H267-I317.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850755
Product Specific Information
Antibody detects endogenous levels of total Cytochrome P450 3A4/5.
Target Information
CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; Albendazole monooxygenase (sulfoxide-forming); Albendazole sulfoxidase; aryl hydrocarbon hydroxylase; Cholesterol 25-hydroxylase; CYPIIIA3; CYPIIIA4; CYPIIIA5; Cytochrome P450 3A3; Cytochrome P450 3A4; Cytochrome P450 3A5; Cytochrome P450 HLp; cytochrome P450 HLp2; Cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; Cytochrome P450-PCN1; Cytochrome P450-PCN3; flavoprotein-linked monooxygenase; glucocorticoid-inducible P450; HLp2; microsomal monooxygenase; Nifedipine oxidase; P450-III, steroid inducible; P450-PCN3; Quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase; xenobiotic monooxygenase
Gene Aliases: CP33; CP34; CP35; CYP3A; CYP3A3; CYP3A4; CYP3A5; CYPIIIA3; CYPIIIA4; CYPIIIA5; HLP; NF-25; P450C3; P450PCN1; P450PCN3; PCN3
UniProt ID: (Human) P08684, (Human) P20815
Entrez Gene ID: (Human) 1576, (Human) 1577
monooxygenase activity
steroid binding
iron ion binding
steroid hydroxylase activity
oxidoreductase activity
oxygen binding
enzyme binding
heme binding
vitamin D3 25-hydroxylase activity
taurochenodeoxycholate 6alpha-hydroxylase activity
caffeine oxidase activity
albendazole monooxygenase activity
quinine 3-monooxygenase activity
testosterone 6-beta-hydroxylase activity
aromatase activity
vitamin D 24-hydroxylase activity
oxygenase
lipid metabolic process
steroid catabolic process
xenobiotic metabolic process
steroid metabolic process
androgen metabolic process
alkaloid catabolic process
monoterpenoid metabolic process
drug metabolic process
calcitriol biosynthetic process from calciol
vitamin D metabolic process
drug catabolic process
exogenous drug catabolic process
heterocycle metabolic process
oxidation-reduction process
oxidative demethylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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