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CYP7B1 Antibody (PA5-75380) in IHC (P)
Immunohistochemistry analysis of CYP7B1 in paraffin-embedded human breast carcinoma tissue (strong membranous and cytoplasmic staining) and negative control (right, with PBS only). Samples were incubated with CYP7B1 polyclonal antibody (Product # PA5-75380) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-75380
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 101-150 of Human CYP7B1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2719108
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 24-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; Cytochrome P450 7B1; cytochrome P450, 7b1; cytochrome P450, subfamily 7B, polypeptide 1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1; HCT-1; Hippocampal transcript 1 protein; Oxysterol 7-alpha-hydroxylase
Gene Aliases: AW261589; CBAS3; CP7B; CYP7B1; D3Ertd552e; hct-1; SPG5A
UniProt ID: (Human) O75881, (Mouse) Q60991, (Rat) Q63688
Entrez Gene ID: (Human) 9420, (Mouse) 13123, (Rat) 25429
bile acid biosynthetic process
cholesterol metabolic process
sterol metabolic process
negative regulation of intracellular estrogen receptor signaling pathway
B cell chemotaxis
positive regulation of epithelial cell proliferation
oxidation-reduction process
prostate gland epithelium morphogenesis
lipid metabolic process
digestion
memory
circadian rhythm
steroid metabolic process
response to drug
response to cAMP
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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