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产品信息
PA5-70099
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the middle region of rat CaMKII beta
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2690050
产品详细信息
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Yeast: 93%; Zebrafish: 100%
靶标信息
CAMK2B (CaMKII beta) is a serine/threonine kinase that plays a role in synaptic plasticity, synaptic vesicle mobilization and regulation of gene expression. As a dominant kinase in the central nervous system it may function in long term potentiation and neurotransmitter release. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ca++/calmodulin-dependent protein kinase II beta subunit; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; caM-kinase II beta chain; caMK-II subunit beta; MGC29528; β CaMKII; βCaMKII
基因别名: Camk2b; Ck2b
UniProt ID: (Rat) P08413
Entrez Gene ID: (Rat) 24245
G1/S transition of mitotic cell cycle
inhibitory G-protein coupled receptor phosphorylation
protein phosphorylation
calcium ion transport
positive regulation of neuron projection development
peptidyl-serine phosphorylation
regulation of synaptic transmission, cholinergic
positive regulation of phospholipase A2 activity
response to cadmium ion
protein autophosphorylation
regulation of long-term neuronal synaptic plasticity
cell projection morphogenesis
neuromuscular process controlling balance
long-term synaptic potentiation
activation of meiosis involved in egg activation
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
positive regulation of apoptotic signaling pathway
