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Positive test controls include: SH-SY5Y, Mouse thymus.
Immunogen sequence: EGEKIQGDGA QAAVKGAQAE LMKVQALEKV KGADINAEEA PKMVPKAVED GIKVADLELE EGLAEEKLKT VEEAAAPREG QGSSAVGFEV PQQDVILPEY
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphoryates CREB, oncoprotein 18, and SRF. It has limited tissue distribution, and has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: brain Ca(2+)-calmodulin-dependent protein kinase type IV; brain Ca++-calmodulin-dependent protein kinase type IV; Ca2+/calmodulin-dependent protein kinase type IV/Gr; Calcium/calmoduli; calcium/calmodulin-dependent protein kinase IV; Calcium/calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase type IV catalytic chain; Calmodulin-dependent protein kinase IV; Calspermin; CAM kinase IV; CAM kinase- GR; CAM kinase-GR; CaMK IV; EC 2.7.11.17; KCC4; kinase CaMK4; OTTHUMP00000222818
基因别名: A430110E23Rik; AI666733; CAMK; CaMK IV; CAMK-GR; CAMK4; CAMKIV; CaMKIV/Gr; Ccdpk; D18Bwg0362e; RATCCDPK
UniProt ID: (Human) Q16566, (Rat) P13234
Entrez Gene ID: (Human) 814, (Mouse) 12326, (Rat) 25050