Invitrogen

CaMKK beta Polyclonal Antibody

CaMKK beta Antibody in Immunocytochemistry (ICC/IF)

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CaMKK beta Antibody (PA5-82589) in ICC/IF

Immunofluorecent analysis of CaMKK beta in human cell line A-431 using CaMKK beta Polyclonal Antibody (Product # PA5-82589). Staining shows localization to cytosol.

CaMKK beta Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-82589

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:200-1:500

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

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产品规格

种属反应

Human

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human CAMKK2. Recombinant protein control fragment (Product #RP-91409).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.4 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2789746

产品详细信息

Immunogen sequence: SSCVSSQPSS NRAAPQDELG GRGSSSSESQ KPCEALRGLS SLSIHLGMES FIVVTECEPG CAVDLGLARD RPLEADGQEV PLDTSGSQAR PHLSGRKLSL QERSQGGLAA GGSLDMNGRC ICPSLPYSPV SSPQSS

靶标信息

CAMKK2 (CaMKK beta) is a serine/threonine kinase involved in neurogenesis, cell differentiation, and signal transduction. It also activates CAMKI and CAMKIV, and plays a role in the development of long term memory.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ.

Cellular and molecular life sciences : CMLS

Wu F,Hill K,Fang Q,He Z,Zheng H,Wang X,Xiong H,Sha SH

PA5-82589 was used in Immunocytochemistry to demonstrate that traumatic-noise-induced OHC loss and hearing loss occur primarily via activation of CaMKKβ.

Tue Apr 19 00:00:00 UTC 2022

生物信息学

蛋白别名: calcium/calmodulin-dependent protein kinase beta; Calcium/calmodulin-dependent protein kinase kinase 2; calcium/calmodulin-dependent protein kinase kinase 2, beta; Calcium/calmodulin-dependent protein kinase kinase beta; caM-kinase kinase 2; caM-kinase kinase beta; CaM-KK 2; CaM-KK beta; CAMKK beta protein; MGC15254

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基因别名: CAMKK; CAMKK2; CAMKKB; KIAA0787

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UniProt ID: (Human) Q96RR4

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Entrez Gene ID: (Human) 10645

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功能

calmodulin-dependent protein kinase activity protein tyrosine kinase activity calcium ion binding calmodulin binding ATP binding

参与通路

MAPK cascade protein phosphorylation peptidyl-tyrosine phosphorylation calcium-mediated signaling regulation of protein kinase activity positive regulation of transcription, DNA-templated protein autophosphorylation