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产品信息
PA5-54163
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human Calcium Channel 1D. Recombinant protein control fragment (Product #RP-102095).
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2639225
产品详细信息
Immunogen sequence: EDPEIHGYFR DPHCLGEQEY FSSEECYEDD SSPTWSRQNY GYYSRYPGRN IDSERPRGYH HPQGFLEDDD SPVCYDSRRS PRRRLLPPTP ASHRRSSFNF ECLRRQSSQE EVPSSPIFPH RTALPLHLMQ QQIMAV
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 85%.
靶标信息
CACNA1D is also known as PASNA, SANDD or Cav1. 3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CACNA 1D; Calcium channel, L type, alpha-1 polypeptide, isoform 2; calcium channel, neuroendocrine/brain-type, alpha 1 subunit; calcium channel, voltage-dependent, L type, alpha 1D subunit; Voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel alpha 1 subunit; voltage-gated calcium channel alpha subunit Cav1.3; Voltage-gated calcium channel subunit alpha Cav1.3
基因别名: CACH3; CACN4; CACNA1D; CACNL1A2; Cav1.3; CCHL1A2; PASNA; SANDD
UniProt ID: (Human) Q01668
Entrez Gene ID: (Human) 776
voltage-gated calcium channel activity
high voltage-gated calcium channel activity
ankyrin binding
metal ion binding
alpha-actinin binding
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
voltage-gated ion channel
calcium ion transport
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
sensory perception of sound
regulation of insulin secretion
positive regulation of calcium ion transport
regulation of atrial cardiac muscle cell membrane repolarization
cardiac conduction
calcium ion import
calcium ion transmembrane transport
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
regulation of potassium ion transmembrane transporter activity
regulation of potassium ion transmembrane transport
