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Calcitonin Receptor Antibody (PA5-33379) in IHC (P)
Immunohistochemistry analysis of Calcitonin Receptor in human Thyroid, Medullary Carcinoma. Samples were incubated with Calcitonin Receptor polyclonal antibody (Product # PA5-33379). Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-33379
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human Calcitonin Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550760
Product Specific Information
Percent identity with other species by BLAST analysis: Human (100%) Gorilla, Marmoset (95%) Gibbon, Monkey (90%) Rabbit (85%) Panda, Dog, Horse (80%).
Target Information
The Calcitonin Receptor inhibits bone resorption. This receptor is expressed during development and is involved in morphogenesis. Three alternatively spliced Calcitonin Receptor isoforms have been identified. In addition to binding calcitonin, the Calcitonin Receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. The Calcitonin Receptor has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcitonin receptor; COPT1; CT receptor; CT-R; hCTR1
Gene Aliases: CALCR; CRT; CT-R; CTR; CTR1
UniProt ID: (Human) P30988
Entrez Gene ID: (Human) 799
cell surface receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
protein transport
positive regulation of cAMP biosynthetic process
receptor internalization
positive regulation of adenylate cyclase activity
response to glucocorticoid
protein localization to plasma membrane
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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