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Alomone Labs, LTD
Calcitonin Receptor (extracellular) Polyclonal Antibody
FIGURE: 1 / 2
Calcitonin Receptor (extracellular) Antibody (ACR-053-200UL) in ICC/IF
Expression of CALCR in rat PC12 cells - Cell surface detection of CALCR in intact living rat pheochromocytoma (PC12) cells. A, C. Extracellular staining of cells using Anti-Calcitonin Receptor (extracellular) Antibody , (#ACR-053), (1:50). B, D. Merged images of A and C, each with its respective live view of the cells.
Product Details
ACR-053-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)HLVEVVPNGDLVRRD, corresponding to amino acid residues 201-215 of rat CALCR, 1st extracellular loop
Conjugate
Form
Lyophilized
Concentration
0.85 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The Calcitonin Receptor inhibits bone resorption. This receptor is expressed during development and is involved in morphogenesis. Three alternatively spliced Calcitonin Receptor isoforms have been identified. In addition to binding calcitonin, the Calcitonin Receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. The Calcitonin Receptor has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C1A/C1B; Calcitonin receptor; COPT1; CT receptor; CT-R; hCTR1
Gene Aliases: Calcr; Clr
UniProt ID: (Rat) P32214, (Mouse) Q60755
Entrez Gene ID: (Rat) 116506, (Mouse) 12311
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
protein transport
negative regulation of ossification
osteoclast differentiation
positive regulation of cAMP biosynthetic process
receptor internalization
regulation of mRNA stability
regulation of bone resorption
positive regulation of adenylate cyclase activity
response to glucocorticoid
protein localization to plasma membrane
signal transduction
cell surface receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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