Invitrogen

Calmyrin Polyclonal Antibody

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说明书
实验方案
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产品信息

PA5-92218

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human CIB1 (NP_0063752)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.37 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2806414

产品详细信息

Immunogen sequence: MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EQRSVESSLR AQVPFEQILS LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD TATPDIKSHY AFRIFDFDDD GTLNREDLSR LVNCLTGEGE DTRLSASEMK QLIDNILEES DIDRDGTINL SEFQHVISRS PDFASSFKIV L; Positive Samples: HepG2, HeLa, DU145, A-549, HT-29, Mouse kidney, Mouse liver; Cellular Location: Apical cell membrane, Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Lipid-anchor, Membrane, Nucleus, centrosome, cytoskeleton, filopodium tip, growth cone, lamellipodium, microtubule organizing center, perinuclear region, ruffle membrane, sarcolemma, trans-Golgi network

靶标信息

The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alphabeta, which may implicate this protein as a regulatory molecule for alphabeta.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: calcium and integrin binding 1 (calmyrin); calcium and integrin binding, protein kinase interacting protein; Calcium and integrin-binding protein 1; Calcium- and integrin-binding protein; Calmyrin; CIB; CIBP; DNA-dependent protein kinase interacting protein; DNA-PK interaction protein; DNA-PKcs-interacting protein; Kinase-interacting protein; KIP; protein kinase, DNA activated, catalytic polypeptide interacting protein; SIP2-28; SNK-interacting protein 2-28; testicular secretory protein Li 9

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基因别名: CIB; CIB1; Cibkip; CIBP; KIP; KIP1; PRKDCIP; SIP2-28

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UniProt ID: (Human) Q99828, (Rat) Q9R010, (Mouse) Q9Z0F4

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Entrez Gene ID: (Human) 10519, (Rat) 81823, (Mouse) 23991

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功能
calcium ion binding protein binding protein C-terminus binding calcium-dependent protein kinase inhibitor activity Ras GTPase binding protein kinase binding protein serine/threonine kinase inhibitor activity protein anchor ion channel binding metal ion binding
参与通路
angiogenesis negative regulation of protein phosphorylation positive regulation of protein phosphorylation positive regulation of cell-matrix adhesion response to ischemia double-strand break repair apoptotic process cellular response to DNA damage stimulus negative regulation of microtubule depolymerization endomitotic cell cycle cell adhesion spermatid development positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of neuron projection development platelet formation positive regulation of cell growth positive regulation of cell migration cytoplasmic microtubule organization positive regulation of cell adhesion mediated by integrin thrombopoietin-mediated signaling pathway regulation of cell proliferation negative regulation of apoptotic process positive regulation of catalytic activity negative regulation of megakaryocyte differentiation positive regulation of NF-kappaB transcription factor activity cell division regulation of cell division negative regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade positive regulation of calcineurin-NFAT signaling cascade cellular response to tumor necrosis factor cellular response to growth factor stimulus negative regulation of protein serine/threonine kinase activity positive regulation of protein serine/threonine kinase activity positive regulation of establishment of protein localization to plasma membrane positive regulation of cell migration involved in sprouting angiogenesis positive regulation of protein targeting to membrane extrinsic apoptotic signaling pathway positive regulation of substrate adhesion-dependent cell spreading cellular response to nerve growth factor stimulus positive regulation of male germ cell proliferation negative regulation of protein kinase activity cell cycle spermatogenesis cell differentiation
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