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产品信息
PA5-20592
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid peptide from near the carboxy terminus of human CAPN6.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11154625
产品详细信息
A suggested positive control is rat lung tissue lysate.
PA5-20592 can be used with blocking peptide PEP-0712.
靶标信息
Calpain-6, also known as calpamodulin or calpain-X, is an intracellular, calcium-dependent cysteine protease. Calpain-6 has a much more tissue-specific expression in adults than the ubiquitous calpain-1 and calpain-2, and has thus far been found primarily in the placenta, although it is expressed embryonically in a number of tissues. The classical calpain family members consist of a common small subunit (calpain-4), and a large variable subunit, but it is not known if calpain-6 associates with a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain T in calpains 5 and 6). Located on the X chromosome, the calpain-6 sequence lacks the "EF hand" calcium-binding motif found in domain-IV of the classical calpains. In addition, the canonical active site Cys, His and Asn are modified to Lys, His, Asn in human and Lys, Tyr, Asn in mouse calpain-6, making it unlikely that calpain-6 is proteolytically active.
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生物信息学
蛋白别名: Calpain-6; Calpain-like protease X-linked; Calpamodulin; CalpM
基因别名: CALPM; CANPX; Capa6; CAPN6; CAPNX; DJ914P14.1
UniProt ID: (Human) Q9Y6Q1, (Mouse) O35646, (Rat) O88501
Entrez Gene ID: (Human) 827, (Mouse) 12338, (Rat) 83685
