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Calponin 1 Antibody (MA5-38095) in IHC (P)
Immunohistochemistry analysis of Calponin 1 in paraffin-embedded human colon. Samples were incubated with Calponin 1 Monoclonal antibody (Product # MA5-38095) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
MA5-38095
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC0232
抗原
A synthetic peptide corresponding to a sequence within amino acids 198-297 of human Calponin (P51911)
偶联物
形式
Liquid
浓度
0.38 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2898013
产品详细信息
Positive Samples: Mouse lung, Mouse kidney, Mouse heart, Rat lung, Rat uterus
Immunogen sequence: PLDQATISLQ MGTNKGASQA GMTAPGTKRQ IFEPGLGMEH CDTLNVSLQM GSNKGASQRG MTVYGLPRQV YDPKYCLTPE YPELGEPAHN HHAHNYYNSA
靶标信息
Calponin, a thin filament associated protein is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34kDa and 29kDa. Expression of the 29kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basic calponin; calponin 1, basic, smooth muscle; calponin 1, smooth muscle; Calponin H1, smooth muscle; Calponin-1; calponins, basic; epididymis secretory protein Li 14
基因别名: CN; CNN1; CnnI; HEL-S-14; Sm-Calp; SMCC
UniProt ID: (Human) P51911, (Mouse) Q08091, (Rat) Q08290
Entrez Gene ID: (Human) 1264, (Mouse) 12797, (Rat) 65204
