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Calreticulin Antibody (PA3-16862) in ICC/IF
Immunofluorescence analysis of Calreticulin was performed using 70% confluent log phase U-2 OS cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Calreticulin Polyclonal Antibody (Product # PA3-16862) at 1:200 dilution in 0.1% BSA, incubated at 4 degree ... View More
产品信息
PA3-16862
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Hamster,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A fusion protein to mouse calreticulin.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2069604
产品详细信息
Suggested positive control: antigen standard for CALR (transient overexpression lysate).
靶标信息
Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Autoantigen RO; CABP3; CALBP; Calcium-binding protein 3; calrectulin; Calregulin; Calreticulin; CRP55; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; Ro/SS-A Antigen; Sicca syndrome antigen A (autoantigen Ro; calreticulin)
基因别名: BOS_7422; CALR; Calregulin; cC1qR; CRP55; CRT; CRTC; ERp60; HACBP; HEL-S-99n; I79_008346; RO; SSA
UniProt ID: (Human) P27797, (Bovine) P52193, (Chinese hamster) Q8K3H7, (Mouse) P14211, (Rat) P18418
Entrez Gene ID: (Human) 811, (Bovine) 281036, (Chinese hamster) 100689096, (Mouse) 12317, (Rat) 64202
complement component C1q binding
glycoprotein binding
DNA binding
mRNA binding
integrin binding
iron ion binding
calcium ion binding
protein binding
zinc ion binding
carbohydrate binding
ubiquitin protein ligase binding
peptide binding
hormone binding
protein binding involved in protein folding
poly(A) RNA binding
androgen receptor binding
unfolded protein binding
chaperone binding
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
peptide antigen assembly with MHC class I protein complex
protein folding
protein export from nucleus
cell cycle arrest
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of translation
cortical actin cytoskeleton organization
negative regulation of intracellular steroid hormone receptor signaling pathway
protein localization to nucleus
regulation of meiotic nuclear division
negative regulation of neuron differentiation
positive regulation of DNA replication
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
positive regulation of phagocytosis
protein stabilization
chaperone-mediated protein folding
cellular senescence
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of dendritic cell chemotaxis
spermatogenesis
response to organic substance
response to estradiol
response to testosterone
response to drug
cardiac muscle cell differentiation
cellular response to lithium ion
cellular response to organic substance
antigen processing and presentation of peptide antigen via MHC class I
regulation of transcription, DNA-templated
cellular calcium ion homeostasis
receptor-mediated endocytosis
protein maturation by protein folding
protein folding in endoplasmic reticulum
ATF6-mediated unfolded protein response
glucocorticoid receptor signaling pathway
regulation of apoptotic process
sequestering of calcium ion
