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产品信息
MA5-37936
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2209
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human Calsequestrin 1 (NP_0012223)
偶联物
形式
Liquid
浓度
1.3 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897856
产品详细信息
Positive Samples: Rat heart
Immunogen sequence: EDKGVGFGLV DSEKDAAVAK KLGLTEVDSM YVFKGDEVIE YDGEFSADTI VEFLLDVLED PVELIEGERE LQAFENIEDE IKLIGYFKSK DSEHYKAFED A
靶标信息
The sarcoplasmic reticulum (SR) is, in part, responsible for maintaining the level of intracellular calcium in cardiac and skeletal muscle by storing and releasing calcium. Several intralumenal SR calcium binding proteins have been identified, the most prominent of these is calsequestrin. Calsequstrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular (terminal cisternae) SR. Calsequestrin functions to localize calcium near the junctional face of the terminal cisternae from which calcium can be released into the cytosol via the ryanodine receptor. This protein is highly acidic and has a large capacity and moderate to low affinity for calcium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aspartactin; Calmitine; Calsequestrin, skeletal muscle isoform; Calsequestrin-1; Laminin-binding protein
基因别名: Casq1; CSQ; CSQ-1; CSQ1; sCSQ
UniProt ID: (Rat) P19633, (Mouse) O09165
Entrez Gene ID: (Rat) 686019, (Mouse) 12372
endoplasmic reticulum organization
skeletal muscle tissue development
response to heat
response to organic substance
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
response to muscle inactivity
response to denervation involved in regulation of muscle adaptation
sarcomere organization
protein polymerization
regulation of sequestering of calcium ion
regulation of muscle contraction
