Invitrogen

Cardiac Troponin I Monoclonal Antibody (16A11)

Cardiac Troponin I Antibody in Western Blot (WB)

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Cardiac Troponin I Antibody (MA1-20112) in WB

Western blot analysis was performed on tissue extracts (30 µg lysate) of Mouse Heart (Lane 1), Rat Heart (Lane 2), Mouse Liver (Lane 3), Mouse Skeletal Muscle (Lane 4) and Mouse Brain (Lane 5). The blot was probed with Anti-Cardiac Troponin I Monoclonal Antibody (16A11) (Product # MA1-20112, 1:500 dilution) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25 µg/ml, 1:4000 dilution). A 24 kDa band corresponding to Cardiac Troponin I was detected only in Mou... View More

Cardiac Troponin I Antibody in ELISA (ELISA)

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产品信息

MA1-20112

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500

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免疫组化 (IHC)

Assay-dependent

查看4篇已发表文章 4篇已发表文章

免疫组化（冰冻） (IHC (F))

查看1篇已发表文章 1篇已发表文章

酶联免疫吸附实验 (ELISA)

Assay-dependent

查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

Assay-dependent

亲和纯化 (AP)

Assay-dependent

产品规格

种属反应

Bovine, Dog, Cat, Goat, Human, Mouse, Pig, Rabbit, Rat

已发表种属

Chicken, Human, Zebrafish

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

16A11

抗原

Full length, human cardiac troponin 1 protein.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

5.9 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

AB_561823

产品详细信息

MA1-20112 detects cardiac troponin 1 in human, mouse, rat, bovine, feline, canine, goat, porcine and rabbit samples.

靶标信息

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Boosting Akt Pathway by Rupatadine Modulates Th17/Tregs Balance for Attenuation of Isoproterenol-Induced Heart Failure in Rats.

Frontiers in pharmacology

Ahmed LA,Mohamed AF,Abd El-Haleim EA,El-Tanbouly DM

Published figure using Cardiac Troponin I monoclonal antibody (Product # MA1-20112) in Western Blot

Tue May 18 00:00:00 UTC 2021

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes.

Nature communications

Miki K,Deguchi K,Nakanishi-Koakutsu M,Lucena-Cacace A,Kondo S,Fujiwara Y,Hatani T,Sasaki M,Naka Y,Okubo C,Narita M,Takei I,Napier SC,Sugo T,Imaichi S,Monjo T,Ando T,Tamura N,Imahashi K,Nishimoto T,Yoshida Y

MA1-20112 was used in Western Blot to study mature sub-populations of cardiomyocytes during cardiac differentiation using human induced pluripotent stem cells.

Mon Jun 21 00:00:00 UTC 2021

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes.

Nature communications

MA1-20112 was used in Western Blot to study mature sub-populations of cardiomyocytes during cardiac differentiation using human induced pluripotent stem cells.

Mon Jun 21 00:00:00 UTC 2021

Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via PINK-mediated autophagy.

International journal of molecular medicine

Yao L,Chen H,Wu Q,Xie K

MA1-20112 was used in an ELISA assay to study the mechanisms by which hydrogen therapy alleviates inflammation and apoptosis in myocardial ischemia/reperfusion injury.

Sun Sep 01 00:00:00 UTC 2019

Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors.

Nucleic acids research

Lei L,Yan SY,Yang R,Chen JY,Li Y,Bu Y,Chang N,Zhou Q,Zhu X,Li CY,Xiong JW

MA120112 was used in immunohistochemistry - frozen section to observe that the mRNA encoding Elongation Factor Tu GTP Binding Domain Containing 2 functions in RNA splicing during neural development

Fri Apr 07 00:00:00 UTC 2017

Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix.

Development (Cambridge, England)

Nagy N,Barad C,Graham HK,Hotta R,Cheng LS,Fejszak N,Goldstein AM

MA120112 was used in immunohistochemistry to elucidate the influence of inductive interactions between epithelium and mesenchyme on enteric nervous system development

Fri Jan 15 00:00:00 UTC 2016

Increased radial glia quiescence, decreased reactivation upon injury and unaltered neuroblast behavior underlie decreased neurogenesis in the aging zebrafish telencephalon.

The Journal of comparative neurology

Edelmann K,Glashauser L,Sprungala S,Hesl B,Fritschle M,Ninkovic J,Godinho L,Chapouton P

MA1-20112 was used in immunohistochemistry to investigate the effect of aging on neurogenesis and its mechanism in zebrafish telencephalon

Sun Sep 01 00:00:00 UTC 2013

The cellular composition of neurogenic periventricular zones in the adult zebrafish forebrain.

The Journal of comparative neurology

Lindsey BW,Darabie A,Tropepe V

MA1-20112 was used in immunohistochemistry to investigate neurogenic periventricular zones in the adult zebrafish forebrain

Sun Jul 01 00:00:00 UTC 2012

Neuronal and glial localization of alpha(2A)-adrenoceptors in the adult zebrafish (Danio rerio) brain.

The Journal of comparative neurology

Ampatzis K,Kentouri M,Dermon CR

MA1-20112 was used in immunohistochemistry to localize alpha(2A)-adrenoceptors in the adult zebrafish brain

Thu May 01 00:00:00 UTC 2008

生物信息学

蛋白别名: Cardiac troponin I; cardiac troponin I isoform; cardiomyopathy, dilated 2A (autosomal recessive); cTnI; MGC116817; Tpn1; troponin 1, type 3; troponin I type 3 (cardiac); Troponin I, cardiac muscle

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基因别名: BOS_18114; CMD1FF; CMD2A; CMH7; Ctni; RCM1; Tn1; TnI; TNNC1; TNNI3