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产品信息
PA5-43748
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human CTF1 (aa 1-50).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2607693
产品详细信息
Peptide sequence: MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ
Sequence homology: Cow: 93%; Dog: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 92%; Rat: 86%
靶标信息
Cardiotrophin-1 (CT-1) is a member of the IL-6 family of cytokines, which signal through gp130 receptor complexes. gp130 complexes with several different receptor subunits to transmit signals from Cardiotrophin-1, IL-6, LIF, OSM, CNTF and IL-11. Cardiotrophin-1 binds to and activates the leukemia inhibitory factor (LIF) receptor/gp130 receptor complex and has been shown to induce hypertrophy in cardiac myocytes in vitro. Cardiotrophin-1, a secreted protein expressed at high levels in myocardium during cardiogenesis, has been shown to promote proliferation and survival of embryonic cardiomyocytes, suggesting a role for Cardiotrophin-1 in the activation of gp130 during cardiac development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cardiophin 1; Cardiotrophin; Cardiotrophin-1; Cardiotrophin1; CT 1; CT-1; CT-1CT1; CTF 1
基因别名: CT-1; CT1; CTF1
UniProt ID: (Human) Q16619
Entrez Gene ID: (Human) 1489
cell surface receptor signaling pathway
cell-cell signaling
nervous system development
muscle organ development
cell proliferation
positive regulation of cell proliferation
positive regulation of tyrosine phosphorylation of Stat3 protein
neuron development
leukemia inhibitory factor signaling pathway
