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CatSper1 (extracellular) Antibody (ACC-301-200UL) in WB
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4)testislysates: - 1.2, Anti-CatSper1 (extracellular) Antibody (#ACC-301), (1:200).3.4, Anti-CatSper1 (extracellular) Antibody , preincubated with CatSper1 (extracellular) Blocking Peptide (#BLP-CC301).
产品信息
ACC-301-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RALFQDSDPKRFQN, corresponding to amino acid residues 508-521 of mouse CatSper1, 3rd extracellular loop
偶联物
形式
Lyophilized
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cation channel of sperm 1; Cation channel sperm-associated protein 1; cation channel, sperm associated 1; CatSper1; sperm ion channel; sperm protein CATSPER1
基因别名: Catsper; Catsper1; KSper
UniProt ID: (Mouse) Q91ZR5
Entrez Gene ID: (Mouse) 225865, (Rat) 689349
transport
ion transport
calcium ion transport
multicellular organism development
spermatogenesis
fusion of sperm to egg plasma membrane
cell differentiation
sperm motility
regulation of ion transmembrane transport
regulation of calcium ion transport
transmembrane transport
regulation of cilium beat frequency involved in ciliary motility
calcium ion import
calcium ion transmembrane transport
membrane depolarization during action potential
