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Cathepsin C Antibody (PA5-47049) in IHC (F)
Immunohistochemical analysis of Cathepsin C in perfusion fixed frozen sections of mouse thymus. Samples were incubated in Cathepsin C polyclonal antibody (Product # PA5-47049) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to thymocytes.
产品信息
PA5-47049
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Cathepsin C/DPPI Asp25-Leu462
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2608218
产品详细信息
In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) Cathepsin C is observed and less than 1% cross-reactivity with recombinant mouse (rm) Cathepsin A, rmCathepsin B, rmCathepsin D, rmCathepsin H, and rmCathepsin X/Z/P is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Cathepsin C, known also as dipeptidyl aminopeptidase I (DPPI), is a tetrameric lysosomal cysteine peptidase belonging to the papain family. Cathepsin C is involved in intracellular protein degradation and the processing of protein precursors, where it participates in cell growth, neuraminidase activation, and platelet factor XIII activation. Cathepsin C is largely related to other lysosomal cysteine proteinases, including cathepsin B, H and L. Enzymatically, Cathepsin C is capable of sequentially removing dipeptides from the amino terminus, and it requires halide ions, namely chloride ions, and thiols for complete enzymatic activity. Protein levels of Cathepsin C are detected in a variety of tissues, and it is most highly expressed in spleen, kidney, cytotoxic lymphocytes and myeloid cells, where it localizes to the secretory granule compartment. Cathepsin C is initially synthesized as a proenzyme that is rapidly processed to generate two distinct chains that function together as the mature form of the enzyme.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cathepsin C; Cathepsin J; Dipeptidyl peptidase 1; Dipeptidyl peptidase I; Dipeptidyl transferase; dipeptidyl-peptidase; dipeptidyl-peptidase 1; dipeptidyl-peptidase I; dipeptidylpeptidase 1; DPP-I
基因别名: AI047818; CATC; Ctsc; DPP-I; DPP1; DPPI
UniProt ID: (Mouse) P97821, (Rat) P80067
Entrez Gene ID: (Mouse) 13032, (Rat) 25423
cysteine-type endopeptidase activity
serine-type endopeptidase activity
peptidase activity
cysteine-type peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
peptidase activator activity involved in apoptotic process
hydrolase activity
phosphatase binding
chloride ion binding
identical protein binding
protein self-association
chaperone binding
cysteine protease
T cell mediated cytotoxicity
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to organic substance
positive regulation of peptidase activity
proteolysis involved in cellular protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
positive regulation of apoptotic signaling pathway
aging
