Invitrogen

Cathepsin H/K/L/V Recombinant Rabbit Monoclonal Antibody (ARC1276)

View all (3) Cathepsin H/K/L/V antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-35614

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC1276

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Cathepsin L/V/K/H (P07711)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849514

Product Specific Information

Immunogen sequence: AVWEKNMKMI ELHNQEYREG KHSFTMAMNA FGDMTSEEFR QVMNGFQNRK PRKGKVFQEP LFYEAPRSVD WREKGYVTPV KNQGQCGSCW AFSATGALEG Q

Target Information

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aleurain; Cat H; Cat K; Cat L; Cathepsin B3; Cathepsin BA; Cathepsin K; Cathepsin L1; Cathepsin L2; cathepsin L2, preproprotein; Cathepsin O; cathepsin O1; Cathepsin O2; Cathepsin U; Cathepsin V; Cathepsin X; CP-2; Cyclic protein 2; furless; Major excreted protein; MEP; minisatellite 10q detected by probe MMS10; N-benzoylarginine-beta-naphthylamide hydrolase; nackt; p39 cysteine proteinase; Pro-cathepsin H; Procathepsin L

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Gene Aliases: 1190035F06Rik; ACC-4; ACC-5; ACC4; ACC5; AI323530; AL022844; CATHL; catK; CATL; CATL2; CPSB; CTS02; CTSH; CTSK; CTSL; CTSL1; CTSL2; CTSO; CTSO1; CTSO2; CTSU; CTSV; fs; MEP; MMS10-Q; Ms10q; nkt; PKND; PYCD; UNQ268/PRO305

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UniProt ID: (Human) P09668, (Human) P43235, (Human) P07711, (Human) O60911, (Rat) P00786, (Mouse) P49935, (Rat) O35186, (Mouse) P55097, (Mouse) P06797, (Rat) P07154

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Entrez Gene ID: (Human) 1512, (Human) 1513, (Human) 1514, (Human) 1515, (Rat) 25425, (Mouse) 13036, (Rat) 29175, (Mouse) 13038, (Mouse) 13039, (Rat) 25697

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Function(s)
endopeptidase activity aminopeptidase activity cysteine-type endopeptidase activity serine-type endopeptidase activity protein binding peptidase activity cysteine-type peptidase activity cysteine-type endopeptidase activator activity involved in apoptotic process HLA-A specific activating MHC class I receptor activity thyroid hormone binding fibronectin binding collagen binding proteoglycan binding histone binding serpin family protein binding cysteine-type carboxypeptidase activity kininogen binding protein complex binding peptide binding peptidase activator activity involved in apoptotic process protein self-association hydrolase activity cysteine protease
Process(es)
metanephros development T cell mediated cytotoxicity adaptive immune response immune response-regulating signaling pathway proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cell proliferation positive regulation of gene expression positive regulation of epithelial cell migration neuropeptide catabolic process bradykinin catabolic process positive regulation of peptidase activity antigen processing and presentation positive regulation of cell migration zymogen activation protein destabilization response to retinoic acid membrane protein proteolysis negative regulation of apoptotic process surfactant homeostasis cellular protein metabolic process positive regulation of angiogenesis proteolysis involved in cellular protein catabolic process dichotomous subdivision of terminal units involved in lung branching ERK1 and ERK2 cascade cellular response to thyroid hormone stimulus positive regulation of apoptotic signaling pathway intramembranous ossification toll-like receptor signaling pathway extracellular matrix disassembly collagen catabolic process bone resorption regulation of mitophagy positive regulation of protein targeting to mitochondrion antigen processing and presentation of exogenous peptide antigen via MHC class II macrophage apoptotic process spermatogenesis cellular response to starvation response to glucose multicellular organism aging negative regulation of keratinocyte proliferation protein autoprocessing nerve development hair follicle morphogenesis response to gonadotropin decidualization autophagic cell death response to glucocorticoid Sertoli cell differentiation regulation of actin cytoskeleton reorganization cell communication protein processing catagen epithelial tube branching involved in lung morphogenesis male gonad development response to organic cyclic compound
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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