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产品信息
PA5-78926
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human Caveolin-2 (1-17aa MGLETEKADVQLFMDDD).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746042
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: caveolae; caveolae protein, 20-kD; caveolin 2 isoform a and b; Caveolin-2; MGC12294; Phospho-CAV2
基因别名: AI447843; CAV; CAV2
UniProt ID: (Human) P51636, (Mouse) Q9WVC3, (Rat) Q2IBC5
Entrez Gene ID: (Human) 858, (Mouse) 12390, (Rat) 363425
protein binding
protein kinase binding
protein binding, bridging
protein complex scaffold
protein homodimerization activity
protein heterodimerization activity
scaffold protein binding
SNARE binding
syntaxin binding
mitogen-activated protein kinase kinase kinase binding
D1 dopamine receptor binding
phosphoprotein binding
scaffold/adaptor protein
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
vesicle fusion
mitochondrion organization
endoplasmic reticulum organization
regulation of mitotic nuclear division
insulin receptor signaling pathway
vesicle organization
receptor-mediated endocytosis of virus by host cell
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of MAPK cascade
positive regulation of GTPase activity
positive regulation by host of viral release from host cell
positive regulation by host of viral process
vesicle docking
skeletal muscle fiber development
protein oligomerization
positive regulation of dopamine receptor signaling pathway
caveola assembly
endocytosis
chemical synaptic transmission
negative regulation of cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein localization to nucleus
