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产品信息
PA5-33416
产品规格
种属反应
Bat,
Bovine,
Dog,
Horse,
Human,
Rabbit
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 19 amino acid peptide from kinase domain of human CDC7.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550796
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Opossum (100%).
靶标信息
CDC7 is a cell division cycle 7 homolog protein that is critical for the G1/S transition and is also essential for initiation of DNA replication as cell division occurs. CDC7 is expressed in many normal tissues, but the overexpression of CDC7 may be associated with neoplastic transformation for some tumors and transformed cell lines. CDC7/DBF4 kinase promotes S phase by alleviating an inhibitory activity in Mcm4 that evolved to integrate several protein kinase. CDC7 encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; Cdc7 Kinase; CDC7-like 1; CDC7-related kinase; cell division cycle 7 homolog; cell division cycle 7-like protein 1; Cell division cycle 7-related protein kinase; MGC117361; MGC126237; MGC126238; MGC91067
基因别名: CDC7; CDC7L1; HsCDC7; Hsk1; huCDC7
UniProt ID: (Human) O00311
Entrez Gene ID: (Dog) 479955, (Human) 8317, (Rabbit) 100343407, (Bovine) 516094, (Horse) 100060468
G1/S transition of mitotic cell cycle
double-strand break repair via break-induced replication
DNA replication
DNA replication initiation
phagocytosis
positive regulation of cell proliferation
regulation of cell shape
positive regulation of nuclear cell cycle DNA replication
positive regulation of G2/M transition of mitotic cell cycle
peptidyl-serine phosphorylation
cell cycle phase transition
cell division
