Invitrogen

Chromogranin A Monoclonal Antibody (PHE5)

Chromogranin A Antibody in Immunocytochemistry (ICC/IF)

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Chromogranin A Antibody (MA5-13281) in ICC/IF

Immunofluorescence analysis of Chga was performed using 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Chromogranin A Monoclonal Antibody (PHE5) (Product # MA5-13281) at 1:100 dilution in 0.1% BSA, incubated at 4 d... View More

Chromogranin A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

MA5-13281

应用

建议稀释比

已发表文章

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

0.5-1.0 µg/mL

免疫细胞化学 (ICC/IF)

1:100

产品规格

种属反应

Human, Non-human primate

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

PHE5

抗原

Human pheochromocytoma

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.4, with 0.2% BSA

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

AB_10977528

产品详细信息

MA5-13281 targets Chromogranin A in IF and IHC (P) applications and shows reactivity with Human and Non-human primate samples.

The MA5-13281 immunogen is human pheochromocytoma.

靶标信息

Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Bevacizumab plus octreotide and metronomic capecitabine in patients with metastatic well-to-moderately differentiated neuroendocrine tumors: the XELBEVOCT study.

BMC cancer

Berruti A,Fazio N,Ferrero A,Brizzi MP,Volante M,Nobili E,Tozzi L,Bodei L,Torta M,D'Avolio A,Priola AM,Birocco N,Amoroso V,Biasco G,Papotti M,Dogliotti L

MA5-13281 was used in immunohistochemistry to study the performance of the XELBEVOCT therapeutic regimen in patients with well-to-moderately differentiated neuroendocrine tumors

Fri Mar 14 00:00:00 UTC 2014

Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases.

The American journal of surgical pathology

Volante M,Daniele L,Asioli S,Cassoni P,Comino A,Coverlizza S,De Giuli P,Fava C,Manini C,Berruti A,Papotti M

MA5-13281 was used in immunohistochemistry to study the association of tumor staging with clinical outcome in neuroendocrine tumors of the appendix

Mon Apr 01 00:00:00 UTC 2013

Human ASH-1 promotes neuroendocrine differentiation in androgen deprivation conditions and interferes with androgen responsiveness in prostate cancer cells.

The Prostate

Rapa I,Volante M,Migliore C,Farsetti A,Berruti A,Vittorio Scagliotti G,Giordano S,Papotti M

MA5-13281 was used in immunohistochemistry to study the role of the human ASH-1 transcription factor in the development of the prostate cancer cell neuroendocrine phenotype

Thu Aug 01 00:00:00 UTC 2013

Human papillomavirus-associated adenocarcinoma of the base of the tongue.

Human pathology

Hanna J,Reimann JD,Haddad RI,Krane JF

MA5-13281 was used in immunohistochemistry to report on two cases of adenocarcinoma of the base of the tongue associated with HPV infection

Thu Aug 01 00:00:00 UTC 2013

HPV-associated neuroendocrine carcinoma of the oropharynx: a rare new entity with potentially aggressive clinical behavior.

The American journal of surgical pathology

Kraft S,Faquin WC,Krane JF

MA5-13281 was used in immunohistochemistry to report on 8 cases of HPV- and tobacco-associated neuroendocrine carcinoma of the oropharynx

Thu Mar 01 00:00:00 UTC 2012

Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma.

Virchows Archiv : an international journal of pathology

Righi L,Rapa I,Votta A,Papotti M,Sapino A

MA5-13281 was used in immunohistochemistry to study the expression of the hASH-1 transcription factor in neuroendocrine breast carcinoma

Sun Apr 01 00:00:00 UTC 2012

Pulmonary meningothelial-like nodules: new insights into a common but poorly understood entity.

The American journal of surgical pathology

Mukhopadhyay S,El-Zammar OA,Katzenstein AL

MA5-13281 was used in immunohistochemistry to study pulmonary meningothelial-like nodules

Wed Apr 01 00:00:00 UTC 2009

Laparoscopic resection of urinary bladder paraganglioma: a case report.

Surgical laparoscopy, endoscopy & percutaneous techniques

Dilbaz B,Bayoglu Y,Oral S,Cavusoglu D,Uluoglu O,Dilbaz S

MA5-13281 was used in immunohistochemistry to report on a case of aparoscopic resection of urinary bladder paraganglioma

Wed Feb 01 00:00:00 UTC 2006

Pulmonary large cell carcinoma with rhabdoid phenotype.

Annals of diagnostic pathology

Yilmazbayhan D,Ates LE,Dilege S,Gulluoglu M,Tanju S,Kalayci G

MA5-13281 was used in immunohistochemistry The report on a patient with pulmonary large cell carcinoma with rhabdoid phenotype

Mon Aug 01 00:00:00 UTC 2005

Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions.

The Tohoku journal of experimental medicine

Deveci MS,Deveci G

MA5-13281 was used in immunohistochemistry to study the altered distribution of metaplastic cell types in atrophic gastritic mucosa with endocrine cell lesions

Thu Jan 01 00:00:00 UTC 2004

Classification of low-grade neuroendocrine tumors of midgut and unknown origin.

Human pathology

Van Eeden S,Quaedvlieg PF,Taal BG,Offerhaus GJ,Lamers CB,Van Velthuysen ML

MA5-13281 was used in immunohistochemistry to study whether refining the grading of low-grade neuroendocrine tumors of the midgut and unknown origin is of prognostic/predictive value

Fri Nov 01 00:00:00 UTC 2002

生物信息学

蛋白别名: AL-11; betagranin (N-terminal fragment of chromogranin A); Catestatin; CgA; chromofungin; Chromogranin-A; CTNNB; DKFZp686D02253; EA-92; ER-37; ES-43; FLJ25606; FLJ37923; GE-25; GR-44; GV-19; LF-19; MGC105435; p-Glu serpinin precursor; Pancreastatin; parathyroid secretory protein 1; Pituitary secretory protein I; Serpinin; Serpinin-RRG; SL21; SP-I; SS-18; Vasostatin I; Vasostatin II; Vasostatin-1; Vasostatin-2; WA-8; WE-14

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基因别名: CGA; CHGA

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UniProt ID: (Human) P10645

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Entrez Gene ID: (Human) 1113

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