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产品信息
OSC00284W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 300-350 of human Clusterin conjugated to an immunogenic carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Clusterin alpha chain.
靶标信息
Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Aging-associated gene 4 protein; aging-associated protein 4; Apo-J; Apolipoprotein J; CLI; Clusterin; Complement cytolysis inhibitor; complement lysis inhibitor; Complement-associated protein SP-40,40; Ku70-binding protein 1; NA1/NA2; SGP-2; Sulfated glycoprotein 2; Testosterone-repressed prostate message 2; TRPM-2
基因别名: AAG4; APO-J; APOJ; CLI; CLU; CLU1; CLU2; KUB1; NA1/NA2; SGP-2; SGP2; SP-40; TRPM-2; TRPM2
UniProt ID: (Human) P10909
Entrez Gene ID: (Human) 1191
cell morphogenesis
microglial cell activation
release of cytochrome c from mitochondria
platelet degranulation
lipid metabolic process
complement activation
complement activation, classical pathway
aging
positive regulation of cell proliferation
response to light stimulus
response to wounding
response to virus
protein import
endocrine pancreas development
central nervous system myelin maintenance
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein homooligomerization
positive regulation of tumor necrosis factor production
response to potassium ion
reverse cholesterol transport
estrous cycle
innate immune response
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
neuron projection morphogenesis
protein stabilization
positive regulation of NF-kappaB transcription factor activity
chaperone-mediated protein complex assembly
response to misfolded protein
chaperone-mediated protein folding
microglial cell proliferation
cellular response to growth factor stimulus
regulation of beta-amyloid clearance
regulation of neuron death
positive regulation of neuron death
positive regulation of beta-amyloid formation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of beta-amyloid formation
regulation of neuronal signal transduction
positive regulation of tau-protein kinase activity
positive regulation of neurofibrillary tangle assembly
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
