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产品信息
PA5-79057
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Collagen II1222-1241aa AFAGLGQREKGPDPMQYMRA).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746173
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-1 type II collagen; CGA; chondrocalcin; Collagen 2; Collagen alpha-1(II) chain; collagen type II (Col2A1) gene, enhancer region; disproportionate micromelia; MGC131516; Procollagen II alpha 1; procollagen, type II, alpha 1
基因别名: CG2A1A; Col2; Col2a; Col2a-1; Col2a1; COLLII; Del1; Dmm; Lpk; M100856; Rgsc856
UniProt ID: (Rat) P05539, (Mouse) P28481
Entrez Gene ID: (Rat) 25412, (Mouse) 12824
skeletal system development
cartilage condensation
tissue homeostasis
endochondral ossification
chondrocyte differentiation
heart morphogenesis
growth plate cartilage development
proteoglycan metabolic process
central nervous system development
visual perception
sensory perception of sound
response to mechanical stimulus
response to X-ray
regulation of gene expression
collagen fibril organization
notochord development
limb morphogenesis
inner ear morphogenesis
skeletal system morphogenesis
inner ear development
cartilage development
palate development
limb bud formation
embryonic skeletal joint morphogenesis
bone development
cartilage development involved in endochondral bone morphogenesis
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to vitamin E
cellular response to nicotine
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
cellular response to peptide hormone stimulus
otic vesicle development
cellular response to BMP stimulus
response to fibroblast growth factor
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
