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Complement C4 Antibody (PA5-145285) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Complement C4 in Human Liver cancer Tissue. Samples were incubated in Complement C4 polyclonal antibody (Product # PA5-145285) using a dilution of 30 µg/mL followed by HRP-Linked Caprine Anti-Rabbit IgG at a dilution of 2 µg/mL and DAB staining.
产品信息
PA5-145285
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human C4 protein, Asn975-Arg1336 (Accession #P0C0L4)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% Proclin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3093674
靶标信息
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acidic C4; Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4A anaphylatoxin; Chido form of C4; Complement C4-A; Complement C4-B; complement C4B1a; DADB-112B14.11; DAMC-258G8.6; FLJ60561; MGC164979; MHC class III region complement; Rodgers form of C4
基因别名: C4; C4A; C4A2; C4A3; C4A4; C4A6; C4AD; C4B; C4B1; C4B12; C4B2; C4B3; C4B5; C4B_2; C4BD; C4F; C4S; CH; CO4; CPAMD2; CPAMD3; RG
UniProt ID: (Human) P0C0L4, (Human) Q4LE82, (Human) P0C0L5
Entrez Gene ID: (Human) 720, (Human) 721, (Human) 100293534
proteolysis
inflammatory response
complement activation
complement activation, classical pathway
negative regulation of endopeptidase activity
regulation of complement activation
innate immune response
positive regulation of apoptotic cell clearance
opsonization
detection of molecule of bacterial origin
