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产品信息
PA5-78893
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived rat C5a recombinant protein (Position: D1-R77).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746009
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
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生物信息学
蛋白别名: anaphylatoxin; C4B1; C4B12; C4B2; C4B3; C4B5; C4F; CH; CO4; complement C5; CPAMD3; DADB-112B14.11; FLJ17816; FLJ17822; FLJ60561; MGC142298; MGC164979
基因别名: C5a; Hc; RGD1561905
Entrez Gene ID: (Rat) 362119
in utero embryonic development
leukocyte migration involved in inflammatory response
cellular calcium ion homeostasis
chemotaxis
inflammatory response
complement activation, alternative pathway
complement activation, classical pathway
positive regulation of vascular endothelial growth factor production
negative regulation of norepinephrine secretion
negative regulation of macrophage chemotaxis
negative regulation of dopamine secretion
glucose homeostasis
positive regulation of angiogenesis
positive regulation of chemotaxis
positive regulation of chemokine secretion
