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Connexin 46 Antibody (PA5-11634) in IHC (P)
Immunohistochemistry analysis of Connexin 46 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with Connexin 46 polyclonal antibody (Product # PA5-11634) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
产品信息
PA5-11634
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 108-139 amino acids from the N-terminal region of human GJA3
偶联物
形式
Liquid
浓度
1.2 mg/mL
纯化类型
Size-exclusion - Dialysis, Ammonium sulfate precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10978689
靶标信息
Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46 and C2P3, maps to human chromosome 13q11-q12 and encodes a 46 kDa protein. Cx46, along with Cx50, is principally expressed in the lens of the eye. Cx46 mediates intercellular interactions during development and is necessary for the survival of neural crest cells. Cx46 forms gap junctions that connect lens fiber cells and are crucial for maintaining lens transparency and normal lens function. Mutations of Cx46 result in severe cataracts of the lens. Individual knockouts of Cx46 and Cx50 lead to changes in the rate of lens fiber cell differentiation and cell size, thus the interaction of Cx46 and Cx50 is required for proper organization of fiber cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: connexin 46; Connexin-46; Cx46; gap junction alpha 3; Gap junction alpha-3 protein; gap junction protein, alpha 3, 46kDa
基因别名: CTRCT14; CX46; CZP3; GJA3
UniProt ID: (Human) Q9Y6H8
Entrez Gene ID: (Human) 2700
