Product References
The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia.
BMC biology
Amhaz S,Boëda B,Chouchène M,Colasse S,Dingli F,Loew D,Henri J,Prunier C,Levy L
Published figure using Cullin 2 polyclonal antibody (Product # 51-1800) in Western Blot
Fri Apr 07 00:00:00 UTC 2023
Ubiquitination of NKCC2 by the cullin-RING E3 ubiquitin ligase family in the thick ascending limb of the loop of Henle.
American journal of physiology. Renal physiology
Ares GR
Published figure using Cullin 2 polyclonal antibody (Product # 51-1800) in Western Blot
Wed Mar 01 00:00:00 UTC 2023
MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.
PeerJ
Li Y,Wei Y,Zhang H,Bai Y,Wang X,Li Q,Liu Y,Wang S,Wang J,Wen S,Li J,Zhao W
51-1800 was used in Immunohistochemistry to analyze the role of miR-154-5p in the pathology of cervical cancer in vitro and in vivo.
Mon Jul 10 00:00:00 UTC 2023
Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization.
Proceedings of the National Academy of Sciences of the United States of America
Chen C,Gu L,Matye DJ,Clayton YD,Hasan MN,Wang Y,Friedman JE,Li T
51-1800 was used in Knock Down to suggest that pharmacological inhibition of cullin neddylation represents a therapeutic approach for improving hepatic insulin signaling and lowering blood glucose.
Tue Feb 08 00:00:00 UTC 2022
Determining the Effects of Neddylation on Cullin-RING Ligase-Dependent Protein Ubiquitination.
Current protocols
Wang K,Liu X
51-1800 was used in Western Blot to describe our protocols for the preparation of recombinant CUL2 with or without NEDD8 conjugation, which is further used to quantitatively determine the effect of neddylation on CRL2-dependent protein ubiquitination in vitro.
Tue Mar 01 00:00:00 UTC 2022
Target protein localization and its impact on PROTAC-mediated degradation.
Cell chemical biology
Simpson LM,Glennie L,Brewer A,Zhao JF,Crooks J,Shpiro N,Sapkota GP
51-1800 was used in ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to suggest that the subcellular context of the POI can influence the efficacy of PROTAC-mediated POI degradation.
Thu Oct 20 00:00:00 UTC 2022
Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy.
The Journal of clinical investigation
Liang Y,Lyon RC,Pellman J,Bradford WH,Lange S,Bogomolovas J,Dalton ND,Gu Y,Bobar M,Lee MH,Iwakuma T,Nigam V,Asimaki A,Scheinman M,Peterson KL,Sheikh F
51-1800 was used in Western Blot to identify a desmosomal resident regulatory complex that restricted desmosomal proteome degradation and disease.
Tue Jun 01 00:00:00 UTC 2021
Quantitative analyses for effects of neddylation on CRL2VHL substrate ubiquitination and degradation.
Protein science : a publication of the Protein Society
Wang K,Reichermeier KM,Liu X
Published figure using Cullin 2 polyclonal antibody (Product # 51-1800) in Western Blot
Mon Nov 01 00:00:00 UTC 2021
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System.
Cell chemical biology
Simpson LM,Macartney TJ,Nardin A,Fulcher LJ,Röth S,Testa A,Maniaci C,Ciulli A,Ganley IG,Sapkota GP
51-1800 was used in Western Blotting to study ligand-inducible AdPROM development using HaloPROTAC technology.
Thu Sep 17 00:00:00 UTC 2020
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System.
Cell chemical biology
Simpson LM,Macartney TJ,Nardin A,Fulcher LJ,Röth S,Testa A,Maniaci C,Ciulli A,Ganley IG,Sapkota GP
51-1800 was used in Western Blotting to study ligand-inducible AdPROM development using HaloPROTAC technology.
Thu Sep 17 00:00:00 UTC 2020
Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation.
PLoS pathogens
Tikhmyanova N,Tutton S,Martin KA,Lu F,Kossenkov AV,Paparoidamis N,Kenney S,Salvino JM,Lieberman PM
51-1800 was used in Western Blotting to understand the mechanism of action of C60, with the aim of identifying new approaches for treatment of Epstein-Barr Virus associated tumours.
Sat Jul 01 00:00:00 UTC 2017
Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation.
PLoS pathogens
Tikhmyanova N,Tutton S,Martin KA,Lu F,Kossenkov AV,Paparoidamis N,Kenney S,Salvino JM,Lieberman PM
51-1800 was used in Western Blotting to understand the mechanism of action of C60, with the aim of identifying new approaches for treatment of Epstein-Barr Virus associated tumours.
Sat Jul 01 00:00:00 UTC 2017
Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation.
PLoS pathogens
Tikhmyanova N,Tutton S,Martin KA,Lu F,Kossenkov AV,Paparoidamis N,Kenney S,Salvino JM,Lieberman PM
51-1800 was used in Western Blotting to understand the mechanism of action of C60, with the aim of identifying new approaches for treatment of Epstein-Barr Virus associated tumours.
Sat Jul 01 00:00:00 UTC 2017
An affinity-directed protein missile system for targeted proteolysis.
Open biology
Fulcher LJ,Macartney T,Bozatzi P,Hornberger A,Rojas-Fernandez A,Sapkota GP
511800 was used in western blot to show that expression of von Hippel-Lindau-anti-green fluorescence protein-affinity-directed protein missile results in near-complete degradation of endogenous GFP-VPS34 and PAWS1-GFP
Sat Oct 01 00:00:00 UTC 2016
Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling.
The Journal of biological chemistry
Heir P,Srikumar T,Bikopoulos G,Bunda S,Poon BP,Lee JE,Raught B,Ohh M
51-1800 was used in Immunoprecipitation to characterise the locations and effects of erythropoietin receptor hydroxylation by prolyl hydroxylase 3.
Fri Apr 01 00:00:00 UTC 2016
Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle.
eLife
Mosadeghi R,Reichermeier KM,Winkler M,Schreiber A,Reitsma JM,Zhang Y,Stengel F,Cao J,Kim M,Sweredoski MJ,Hess S,Leitner A,Aebersold R,Peter M,Deshaies RJ,Enchev RI
51-1800 was used in western blot to study the cullin-RING ubiquitin ligase deneddylation cycle and COP9-signalosome activation by structural and kinetic analysis
Thu Mar 31 00:00:00 UTC 2016
Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.
The Journal of biological chemistry
Sandoval D,Hill S,Ziemba A,Lewis S,Kuhlman B,Kleiger G
51-1800 was used in western blot to study the interaction between ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase.
Fri Jan 09 00:00:00 UTC 2015
Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.
The Journal of biological chemistry
Sandoval D,Hill S,Ziemba A,Lewis S,Kuhlman B,Kleiger G
51-1800 was used in western blot to study the interaction between ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase.
Fri Jan 09 00:00:00 UTC 2015
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.
The Journal of clinical investigation
Starokadomskyy P,Gluck N,Li H,Chen B,Wallis M,Maine GN,Mao X,Zaidi IW,Hein MY,McDonald FJ,Lenzner S,Zecha A,Ropers HH,Kuss AW,McGaughran J,Gecz J,Burstein E
Published figure using Cullin 2 polyclonal antibody (Product # 51-1800) in Western Blot
Wed May 01 00:00:00 UTC 2013
DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.
Molecular and cellular biology
Heir P,Sufan RI,Greer SN,Poon BP,Lee JE,Ohh M
Published figure using Cullin 2 polyclonal antibody (Product # 51-1800) in Western Blot
Mon Apr 01 00:00:00 UTC 2013
The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.
The Biochemical journal
Bett JS,Ibrahim AF,Garg AK,Kelly V,Pedrioli P,Rocha S,Hay RT
Published figure using Cullin 2 polyclonal antibody (Product # 51-1800) in Western Blot
Mon Apr 15 00:00:00 UTC 2013
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.
Nature structural & molecular biology
den Besten W,Verma R,Kleiger G,Oania RS,Deshaies RJ
51-1800 was used in western blot to show that NEDD8 links CRL ubiquitin ligase function to the p97 pathway.
Sun Apr 01 00:00:00 UTC 2012
UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.
BMC biology
Bandau S,Knebel A,Gage ZO,Wood NT,Alexandru G
Thu Apr 26 00:00:00 UTC 2012
Neddylation-induced conformational control regulates cullin RING ligase activity in vivo.
Journal of molecular biology
Boh BK,Smith PG,Hagen T
51-1800 was used in western blot to study the effect of neddylation on Cul2 and Cul3 structure.
Fri Jun 03 00:00:00 UTC 2011
Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity.
Molecular biology of the cell
Choo YY,Boh BK,Lou JJ,Eng J,Leck YC,Anders B,Smith PG,Hagen T
51-1800 was used in western blot to elucidate the mechanism through which COP9 signalosome promotes cullin RING ligase activity in vivo.
Thu Dec 01 00:00:00 UTC 2011
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
The Journal of biological chemistry
Mao X,Gluck N,Chen B,Starokadomskyy P,Li H,Maine GN,Burstein E
Fri Sep 16 00:00:00 UTC 2011
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
The Journal of biological chemistry
Mao X,Gluck N,Chen B,Starokadomskyy P,Li H,Maine GN,Burstein E
Fri Sep 16 00:00:00 UTC 2011
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
The Journal of biological chemistry
Mao X,Gluck N,Chen B,Starokadomskyy P,Li H,Maine GN,Burstein E
Fri Sep 16 00:00:00 UTC 2011
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.
Genes & development
Mao X,Gluck N,Li D,Maine GN,Li H,Zaidi IW,Repaka A,Mayo MW,Burstein E
Published figure using Cullin 2 polyclonal antibody (Product # 51-1800) in Western Blot
Wed Apr 01 00:00:00 UTC 2009
Substrate-mediated regulation of cullin neddylation.
The Journal of biological chemistry
Chew EH,Hagen T
51-1800 was used in Western Blotting to suggest a mechanism through which availability of substrate recognition subunits and substrates can regulate the ubiquitin ligase activity.
Fri Jun 08 00:00:00 UTC 2007
Substrate-mediated regulation of cullin neddylation.
The Journal of biological chemistry
Chew EH,Hagen T
51-1800 was used in Western Blotting to suggest a mechanism through which availability of substrate recognition subunits and substrates can regulate the ubiquitin ligase activity.
Fri Jun 08 00:00:00 UTC 2007
Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1alpha interactions.
Oncogene
Knauth K,Bex C,Jemth P,Buchberger A
Thu Jan 19 00:00:00 UTC 2006
Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1alpha interactions.
Oncogene
Knauth K,Bex C,Jemth P,Buchberger A
Thu Jan 19 00:00:00 UTC 2006
Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain.
The Journal of biological chemistry
Lolkema MP,Gervais ML,Snijckers CM,Hill RP,Giles RH,Voest EE,Ohh M
Fri Jun 10 00:00:00 UTC 2005
SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.
Molecular and cellular biology
Vuong BQ,Arenzana TL,Showalter BM,Losman J,Chen XP,Mostecki J,Banks AS,Limnander A,Fernandez N,Rothman PB
51-1800 was used in Western Blotting to show that SOCS-1 localises to the microtubule organising complex (MTOC) and the MTOC-associated 20S proteasome.
Fri Oct 01 00:00:00 UTC 2004
