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Cyclin C Antibody (PA5-93046) in IHC (P)
Immunohistochemistry analysis of Cyclin C in paraffin-embedded human colon carcinoma. Samples were incubated with Cyclin C Polyclonal antibody (Product # PA5-93046) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-93046
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human Cyclin C (NP_0051812)
偶联物
形式
Liquid
浓度
0.95 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806600
产品详细信息
Immunogen sequence: MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIA AATSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS; Positive Samples: MCF7, NIH/3T3, Mouse liver, Mouse kidney, Rat liver; Cellular Location: Nucleus
靶标信息
Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk 8, a novel protein kinase of the cdk family. It is suggested that cyclin C and cdk 8 control RNA polymerase II function. Human cdk 8 cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth regulatory signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cyclin-C; dJ199J3.4 (cyclin C); hSRB11; SRB11 homolog
基因别名: AI451004; AU020987; CCNC; CG1C; CycC
UniProt ID: (Human) P24863, (Mouse) Q62447
Entrez Gene ID: (Human) 892, (Rat) 114839, (Mouse) 51813
transcription initiation from RNA polymerase II promoter
protein phosphorylation
protein ubiquitination
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription from RNA polymerase II promoter
negative regulation of triglyceride metabolic process
positive regulation of phosphorylation of RNA polymerase II C-terminal domain
regulation of cyclin-dependent protein serine/threonine kinase activity
transcription, DNA-templated
regulation of transcription, DNA-templated
