Invitrogen

Cyclin D2 Monoclonal Antibody (DCS3.1)

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Cyclin D2 Antibody (MA1-12297) in WB

Journal of diabetes investigation 2019 - Figure 7 Insulin secretion and change in messenger ribonucleic acid expression levels in MIN 6-K8 beta-cells. (a) Effects of glucose, glimepiride and nifedipine on insulin secretion in MIN 6-K8 beta-cells. Insulin secretion from MIN 6-K8 beta-cells was normalized by cellular insulin content ( n = 7 per group). (b, c) Messenger ribonucleic acid expression levels of cyclinD2 and Irs2 in MIN 6-K8 beta-cells ( ... View More

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产品信息

MA1-12297

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

查看14篇已发表文章 14篇已发表文章

免疫组化 (IHC)

查看4篇已发表文章 4篇已发表文章

免疫沉淀 (IP)

Assay-dependent

查看2篇已发表文章 2篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Avian, Human, Mouse

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

DCS3.1

抗原

His-tagged recombinant full-length Cyclin D2

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

PBS

内含物

0.08% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2275323

靶标信息

Cyclin D2 is a G1 cyclin required for G1 phase progression and is a strong candidate for a proto-oncogene. Cyclin D2 can phosphorylate pRB when associated with cdk 4 and / or cdk 6.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Functional adenosine triphosphate-sensitive potassium channel is required in high-carbohydrate diet-induced increase in β-cell mass.

Journal of diabetes investigation

Murase M,Seino Y,Maekawa R,Iida A,Hosokawa K,Hayami T,Tsunekawa S,Hamada Y,Yokoi N,Seino S,Hayashi Y,Arima H

MA1-12297 was used in Western Blotting to investigate the role of a high-carbohydrate diet on Β-cell mass (BCM) in mice.

Fri Mar 01 00:00:00 UTC 2019

Functional adenosine triphosphate-sensitive potassium channel is required in high-carbohydrate diet-induced increase in β-cell mass.

Journal of diabetes investigation

Murase M,Seino Y,Maekawa R,Iida A,Hosokawa K,Hayami T,Tsunekawa S,Hamada Y,Yokoi N,Seino S,Hayashi Y,Arima H

MA1-12297 was used in Western Blotting to investigate the role of a high-carbohydrate diet on Β-cell mass (BCM) in mice.

Fri Mar 01 00:00:00 UTC 2019

Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults.

EMBO molecular medicine

Yang Y,Chang BH,Chan L

MA1-12297 was used in western blot to study the role of the GLIS3 transcription factor in normal pancreatic beta-cell maintenance and proliferation in response to a high fat diet in adult mice

Tue Jan 01 00:00:00 UTC 2013

Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.

Cancer research

Zhang Q,Sakamoto K,Liu C,Triplett AA,Lin WC,Rui H,Wagner KU

MA1-12297 was used in immunoprecipitation and western blot to study the ability of cyclin D3 to compensate for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression

Thu Dec 15 00:00:00 UTC 2011

Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.

Cancer research

Zhang Q,Sakamoto K,Liu C,Triplett AA,Lin WC,Rui H,Wagner KU

MA1-12297 was used in immunoprecipitation and western blot to study the ability of cyclin D3 to compensate for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression

Thu Dec 15 00:00:00 UTC 2011

GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1).

Islets

Stein J,Milewski WM,Hara M,Steiner DF,Dey A

MA1-12297 was used in western blot to study the mechanism by which GSK-3 inactivation or depletion promotes beta-cell replication

Tue Jun 07 00:00:00 UTC 2011

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.

Cancer cell

Zhang Q,Gu J,Li L,Liu J,Luo B,Cheung HW,Boehm JS,Ni M,Geisen C,Root DE,Polyak K,Brown M,Richardson AL,Hahn WC,Kaelin WG,Bommi-Reddy A

MA1-12297 was used in western blot to study the role of EglN2 prolyl hydroxylase in breast carcinogenesis

Fri Nov 06 00:00:00 UTC 2009

Adaptive beta-cell proliferation is severely restricted with advanced age.

Diabetes

Rankin MM,Kushner JA

MA1-12297 was used in western blot to study the impact of ageing on adaptive pancreatic beta-cell proliferation

Mon Jun 01 00:00:00 UTC 2009

Cyclin D2 protein stability is regulated in pancreatic beta-cells.

Molecular endocrinology (Baltimore, Md.)

He LM,Sartori DJ,Teta M,Opare-Addo LM,Rankin MM,Long SY,Diehl JA,Kushner JA

MA1-12297 was used in immunohistochemistry and western blot to study the regulation of cyclin D2 protein stability in pancreatic beta-cells

Sun Nov 01 00:00:00 UTC 2009

Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine.

Cancer biology & therapy

Zheng Y,Bie W,Yang R,Perekatt AO,Poole AJ,Tyner AL

MA1-12297 was used in western blot to investigate the role of p21 and p27 in intestinal epithelial regeneraton

Sun Jun 01 00:00:00 UTC 2008

Molecular characterization of spontaneous mesenchymal stem cell transformation.

PloS one

Rubio D,Garcia S,Paz MF,De la Cueva T,Lopez-Fernandez LA,Lloyd AC,Garcia-Castro J,Bernad A

MA1-12297 was used in western blot to investigate the molecular mechanisms of spontaneous mesenchymal stem cell transformation

Wed Jan 02 00:00:00 UTC 2008

Selective cortical interneuron and GABA deficits in cyclin D2-null mice.

Development (Cambridge, England)

Glickstein SB,Moore H,Slowinska B,Racchumi J,Suh M,Chuhma N,Ross ME

MA1-12297 was used in immunohistochemistry to study selective cortical interneuron and GABA deficits in cyclin D2-null mice

Thu Nov 01 00:00:00 UTC 2007

Effects of granulosa cell-specific deletion of Rb in Inha-alpha null female mice.

Endocrinology

Andreu-Vieyra C,Chen R,Matzuk MM

MA1-12297 was used in western blot to investigate the role of RB protein in ovarian tumorigenesis

Wed Aug 01 00:00:00 UTC 2007

Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation.

Development (Cambridge, England)

Pogoriler J,Millen K,Utset M,Du W

MA1-12297 was used in immunohistochemistry to study the role of cyclin D1 in cerebellar development and medulloblastoma formation

Sun Oct 01 00:00:00 UTC 2006

p75NTR enhances PC12 cell tumor growth by a non-receptor mechanism involving downregulation of cyclin D2.

Experimental cell research

Fritz MD,Mirnics ZK,Nylander KD,Schor NF

MA1-12297 was used in western blot to elucidate how p75NTR suppresses cyclin D2 expression in PC12 cells

Sun Oct 15 00:00:00 UTC 2006

Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.

Proceedings of the National Academy of Sciences of the United States of America

Malik A,Afaq F,Sarfaraz S,Adhami VM,Syed DN,Mukhtar H

MA1-12297 was used in western blot to investigate the protective effect of pomegranate fruit juice against prostate cancer

Tue Oct 11 00:00:00 UTC 2005

Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation.

Molecular endocrinology (Baltimore, Md.)

Chen B,Pollard JW

MA1-12297 was used in immunohistochemistry and western blot to study the ability of cyclin D2 to compensate for cyclin D1 loss in estrogen-induced mouse uterine epithelial cell proliferation