Invitrogen

Cyclin L1 Polyclonal Antibody

Cyclin L1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Cyclin L1 Antibody (PA5-36070) in IHC (P)

Immunohistochemistry analysis of Cyclin L1 in paraffin-embedded human breast carcinoma tissue. Samples were incubated with Cyclin L1 polyclonal antibody (Product # PA5-36070) at a dilution of 1:100.

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产品信息

PA5-36070

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

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免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Not Applicable

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acids 460-518 of human Cyclin L1

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2553355

产品详细信息

This antibody detects endogenous protein at a molecular weight of 60 kDa.

Purity is >95% by SDS-PAGE.

靶标信息

FUS/TLS was originally described as fused in Sarcoma is actually related to a number of different cellular processes and correlated to several diseases. FUS binds DNA as a single or double strand, and acts as a site for transcription factors to recognize. Since FUS is well-documented to be involved in liposarcoma, lipoma and leukaemia, it is believed that when its normal housekeeping functions related to transcription are disrupted, normal cells become cancerous. Interestingly, FUS is also associated with the fatal neuron disorder amyotrophic lateral sclerosis; interruption of its normal RNA-binding functions leads to incorrect cellular localization and leads to pathologies of the neuron. Thus, FUS regulation of cellular functions is a critical component of maintenance of healthy cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。