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The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cystatin A (stefin A); cystatin AS; Cystatin-A; Cystatin-AS; Stefin A; Stefin-A
基因别名: AREI; CSTA; PSS4; STF1; STFA
UniProt ID: (Human) P01040
Entrez Gene ID: (Human) 1475