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产品信息
PA1-12250
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat,
Dog,
Human,
Rabbit
已发表种属
Mouse
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Full length recombinant Cytochrome C.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
0.08% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1073969
产品详细信息
A suggested positive control for this product is rat1 cell lysate.
靶标信息
Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CRF; Cytochrome c; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic; cytochrome c, somatic-like; hc1
基因别名: CYC; CYCS; CYCSA; HCS; THC4
UniProt ID: (Dog) P00011, (Human) P99999, (Rat) P62898
Entrez Gene ID: (Dog) 475258, (Human) 54205, (Rat) 25309, (Rabbit) 100341175, (Rabbit) 100357840
mitochondrial electron transport, ubiquinol to cytochrome c
mitochondrial electron transport, cytochrome c to oxygen
apoptotic DNA fragmentation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to reactive oxygen species
protein dephosphorylation
mitochondrion organization
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
cellular respiration
intrinsic apoptotic signaling pathway
response to ischemia
apoptotic process
response to oxidative stress
negative regulation of hydrogen peroxide biosynthetic process
glial cell apoptotic process
hydrogen peroxide metabolic process
positive regulation of cellular respiration
