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Cytokeratin 14/16 Antibody (PA5-36061) in WB
Western blot analysis of Cytokeratin 14/16 in various lysates. Samples were incubated with Cytokeratin 14/16 polyclonal antibody (Product # PA5-36061) using a dilution of 1:500. Lane 1: Myla2059 whole cell lysate (40 µg); Lane 2: EC9706 whole cell lysate (40 µg); Lane 3: SP2/0 whole cell lysate (40 µg); Lane 4: C6 whole cell lysate (40 µg).
产品信息
PA5-36061
产品规格
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the N-terminus of human Cytokeratin 14
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553350
产品详细信息
This antibody detects endogenous protein at a molecular weight of 52 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
In Bowen's disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
