Invitrogen

Cytokeratin Pan Type II Monoclonal Antibody (AE3)

Cytokeratin Pan Type II Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Cytokeratin Pan Type II Antibody (MA1-5762) in IHC (P)

Immunohistochemistry of Cytokeratin Pan Type II in Human breast tissue. Samples were incubated with Cytokeratin Pan Type II monoclonal antibody (Product # MA1-5762).

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产品信息

MA1-5762

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:3,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

Assay-dependent

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免疫组化（冰冻） (IHC (F))

Assay-dependent

免疫细胞化学 (ICC/IF)

Assay-dependent

产品规格

种属反应

Bovine, Chicken, Human, Mouse, Non-human primate, Pig, Rabbit, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

AE3

抗原

Human epidermal keratins from P3 x 63 Ag8 cells

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.1% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_1075178

产品详细信息

MA1-5762 reacts with all basic (type II) human keratins in human samples, including K1, K2, K3, K4, K5, K6, K7 and K8.

MA1-5762 has been successfully used in Western blot, immunohistochemistry and electron microscopy procedures.

The MA1-5762 immunogen is human epidermal keratins.

靶标信息

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Novel immunofluorescence protocol for multimarker assessment of putative disseminating breast cancer stem cells.

Applied immunohistochemistry & molecular morphology : AIMM

Balic M,Rapp N,Stanzer S,Lin H,Strutz J,Szkandera J,Daidone MG,Samonigg H,Cote RJ,Dandachi N

MA1-5762 was used in immunohistochemistry to investigate the efficiency of a new method for the assessment of putative disseminating breast cancer stem cells

Sat Jan 01 00:00:00 UTC 2011

Assessment of the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines.

Research in veterinary science

Chang CY,Chiou PP,Chen WJ,Li YH,Yiu JC,Cheng YH,Chen SD,Lin CT,Lai YS

MA1-5762 was used in western blot to study the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines

Thu Apr 01 00:00:00 UTC 2010

Coexistence of different tissue tumourigenesis in an N-methyl-N-nitrosourea-induced mammary carcinoma model: a histopathological report in Sprague-Dawley rats.

Laboratory animals

Esendagli G,Yilmaz G,Canpinar H,Gunel-Ozcan A,Guc MO,Guc D

MA1-5762 was used in immunohistochemistry to investigate tumourigenesis in non-mammary tissues in the MNU-induced mammary tumour model

Thu Jan 01 00:00:00 UTC 2009

An immunohistochemical study of feline endometrial adenocarcinoma.

Journal of comparative pathology

Gil da Costa RM,Santos M,Amorim I,Lopes C,Pereira PD,Faustino AM

MA1-5762 was used in immunohistochemistry - paraffin section to characterize feline endometrial adenocarcinomas immunohistochemically

Fri May 01 00:00:00 UTC 2009

BMP4 signaling regulates formation of Hertwig's epithelial root sheath during tooth root development.

Cell and tissue research

Hosoya A,Kim JY,Cho SW,Jung HS

MA1-5762 was used in immunohistochemistry to study the role of BMP4 signaling in regulating the formation of Hertwig's epithelial root sheath during tooth root development

Mon Sep 01 00:00:00 UTC 2008

Graft-versus-host-like disease complicating thymoma: lack of AIRE expression as a cause of non-hereditary autoimmunity?

Immunology letters

Offerhaus GJ,Schipper ME,Lazenby AJ,Montgomery E,Morsink FH,Bende RJ,Musler AR,van Lier RA,van Noesel CJ

MA1-5762 was used in immunohistochemistry to report on three cases of graft-versus-host-like enterocolonopathy

Fri Nov 30 00:00:00 UTC 2007

Mediastinal intraoperative radioisotope sentinel lymph node mapping in non-small-cell lung cancer.

Nuclear medicine communications

Atinkaya C,Ozlem Küçük N,Koparal H,Aras G,Sak SD,Ozdemir N

MA1-5762 was used in immunohistochemistry to develop a method to map sentinel lymph nodes in non-small cell lung cancer patients

Mon Aug 01 00:00:00 UTC 2005

Cytokeratin expression in lichen amyloidosus and macular amyloidosis.

Journal of the European Academy of Dermatology and Venereology : JEADV

Apaydin R,Gürbüz Y,Bayramgürler D,Müezzinoglu B,Bilen N

MA1-5762 was used in immunohistochemistry to investigate the expression of cytokeratins in lichen and macular amyloidosis and their diagnostic value

Sat May 01 00:00:00 UTC 2004

生物信息学

蛋白别名: 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; alpha keratin; CK 2e; CK-1; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-72; CK-8; cytokeratin 1; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; Cytokeratin endo A; Cytokeratin otokeratin; cytokeratin type II, component Ia; cytokeratin type II, component Ib/c; cytokeratin type II, component III; Cytokeratin-1; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; Cytokeratin-7; Cytokeratin-72; Cytokeratin-8; Cytokeratin-A; Cytoskeletal 57 kDa keratin; ear specific cytokeratin; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; Epithelial keratin-2e; Hair alpha protein; K1; K2e; K2P; K3; K3 keratin; K4; K5; K6A; K7; K72; K76; K8; kamp-keratin derived antimicrobial peptide; KDAMP; KERA; keratin 1, type II; keratin 2 (epidermal ichthyosis bullosa of Siemens); keratin 2 epidermis; keratin 2, type II; keratin 2A; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6 alpha; keratin 6, inner root sheath, 2; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 72, pseudogene; keratin 72, type II; keratin 76, type II; keratin 8, type II; keratin 86; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 35; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; keratin IV; keratin K3; keratin K6h; keratin protein K6irs; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 59 kDa, component IV; keratin, type II cytoskeletal 60 kDa, component III; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 72; Keratin, type II cytoskeletal 8; Keratin, type II cytoskeletal cochleal; Keratin-1; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6-alpha; Keratin-6A; keratin-6C; Keratin-7; Keratin-72; Keratin-76; Keratin-8; krt1 {ECO:0000250|UniProtKB:P04264}; krt2; krt2 {ECO:0000250|UniProtKB:P35908}; krt4 {ECO:0000250|UniProtKB:P19013}; krt5; krt7; krt7 {ECO:0000250|UniProtKB:P08729}; krt76; MGC116967; MGC116968; mK6-alpha; otokeratin; pan keratin; Sarcolectin; tuftelin interacting protein 8; type II alpha-keratin IIA; type II alpha-keratin IIC; type II cytokeratin A (no.8); type II cytoskeletal cochleal; Type II inner root sheath-specific keratin-K6irs2; type II keratin Kb1; type II keratin Kb2; type II keratin Kb35; type II keratin Kb4; type II keratin Kb7; type II keratin Kb9; type II mesothelial keratin K7; Type-II keratin Kb1; type-II keratin Kb12; Type-II keratin Kb2; Type-II keratin Kb3; Type-II keratin Kb35; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9; type-II keratin-35

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基因别名: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; AA960620; AI507495; AL022697; AU019895; AW108092; AW146334; BB005427; CARD2; CK-2e; CK-3; CK-4; CK-6C; CK-6E; CK-8; CK1; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK4; CYK8; CYKER; D15Wsu77e; DDD; DDD1; EBS2; EHK; EHK1; EndoA; EPPK; HUMCYT2A; K1; K2C7; K2C8; K2e; K3; K4; K5; K6A; K6C; K6D; K6irs; K6IRS2; K7; K8; Kb1; Kb2; KB35; Kb4; Kb7; Kb9; Ker2; keratin; KERIA; KERIB; KO; Krt-2.1; Krt-2.4; Krt-2.8; KRT1; KRT1A; KRT2; Krt2-1; Krt2-17; Krt2-2; Krt2-35; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; KRT2-8; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; KRT6; KRT6A; KRT6C; KRT6D; KRT6IRS2; KRT7; KRT72; Krt72-ps; KRT76; KRT8; Krt86; KRTA; KRTE; mK6[a]; MK6a; NEPPK; PC3; Sak57; SCL; Tfip8; WSN1