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Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji , mouse fibroblast.
Predicted reactivity: Mouse (90%), Rat (89%), Xenopus laevis (81%), Pig (94%), Chicken (92%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: D4; d4 gdi; GDI LYGDI; Ly-GDI; Rho GDI 2; Rho GDP dissociation inhibitor (GDI) beta; Rho GDP-dissociation inhibitor 2; Rho-GDI beta
基因别名: ARHGDIB; D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1; RhoGDI2
UniProt ID: (Human) P52566, (Mouse) Q3TEB3
Entrez Gene ID: (Human) 397, (Mouse) 11857