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产品信息
PA5-66929
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2662216
产品详细信息
Immunogen sequence: MSTETELQVAV KTSAKKDSRK KGQDRSEATL IKRFKGEGVR YKAKL
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
靶标信息
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dab reelin signal transducer 1; Dab, reelin signal transducer, homolog 1; Disabled homolog 1; RP23-356E21.1
基因别名: DAB1
UniProt ID: (Human) O75553
Entrez Gene ID: (Human) 1600
negative regulation of cell adhesion
small GTPase mediated signal transduction
midgut development
adult walking behavior
dendrite development
ventral spinal cord development
cerebellum structural organization
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
radial glia guided migration of Purkinje cell
response to drug
positive regulation of neuron differentiation
positive regulation of protein kinase activity
negative regulation of JAK-STAT cascade
negative regulation of astrocyte differentiation
negative regulation of axonogenesis
Golgi localization
lateral motor column neuron migration
