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DACT1 Antibody (PA5-119971) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded mouse cerebellum tissue using DACT1 Polyclonal Antibody (Product # PA5-119971). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 1% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the DACT1 antibody at a dilutio... View More
产品信息
PA5-119971
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein within human DACT1 aa 637-836
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2913543
产品详细信息
Positive Control: Mouse testis tissue lysate, mouse liver tissue lysate, mouse cerebellum tissue.
Subcellular Location: Cytoplasm, nucleus, synapse.
靶标信息
Dapper homolog 1, an ortholog of Xenopus Dpr, antagonizes Wnt signaling by promoting Dvl degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism. Dapper homolog 1 acts as an interacting protein for Dvl, and the interaction is formed between the DEP (Dishevelled, Egl-10, and pleckstrin) domain of Dvl and the central and C-terminal regions of Dapper homolog 1. The gene for human Dapper homolog 1 is localized on chromosomal region 14q23.1. The protein impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. The protein is also required for normal notochord formation and is downregulated in hepatocellular carcinomas (HCC). It is expressed in human liver and various other tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dapper 1; Dapper antagonist of catenin 1; Dapper homolog 1; dapper, antagonist of beta-catenin, homolog 1; dishevelled-binding antagonist of beta-catenin 1; Frodo homolog; hDPR1; Hepatocellular carcinoma novel gene 3 protein; heptacellular carcinoma novel gene 3; MDpr1; thymus expressed gene 3; Thymus-expressed novel gene 3 protein
基因别名: 4921528D17Rik; AI115603; DACT1; DAPPER; DAPPER1; DPR1; Frd1; FRODO; Frodo1; HDPR1; HNG3; MDpr1; MTNG3; THYEX3
UniProt ID: (Human) Q9NYF0, (Mouse) Q8R4A3
Entrez Gene ID: (Human) 51339, (Mouse) 59036
negative regulation of transcription from RNA polymerase II promoter
Wnt signaling pathway
neural tube development
positive regulation of Wnt signaling pathway
negative regulation of Wnt signaling pathway
regulation of protein stability
negative regulation of protein binding
positive regulation of protein binding
regulation of catenin import into nucleus
positive regulation of catenin import into nucleus
positive regulation of protein catabolic process
negative regulation of JNK cascade
embryonic hindgut morphogenesis
negative regulation of canonical Wnt signaling pathway
regulation of nodal signaling pathway
positive regulation of cellular protein catabolic process
negative regulation of beta-catenin-TCF complex assembly
regulation of Wnt signaling pathway, planar cell polarity pathway
negative regulation of G1/S transition of mitotic cell cycle
gastrulation with mouth forming second
multicellular organism development
nervous system development
positive regulation of fat cell differentiation
embryonic morphogenesis
dendrite morphogenesis
synapse organization
canonical Wnt signaling pathway
