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DAND5 Antibody (MA5-25684) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human endometrium tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a DAND5 monoclonal antibody (Product # MA5-25684).
产品信息
MA5-25684
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI2H3
抗原
Human recombinant protein fragment corresponding to amino acids 23-189 of DAND5 produced in E.coli
偶联物
形式
Liquid
浓度
1.04 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2723044
靶标信息
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CER2CRL2; cerberus 2; Cerberus like-2; cerberus-like 2; Cerberus-like protein 2; Cerl-2; CKTSF1B3MGC126849; Cysteine knot superfamily 1, BMP antagonist 3; DAN domain family member 5; DAN domain family member 5, BMP antagonist; DAN domain family, member 5; FLJ38607; GREM3cerberus 2; Gremlin-3; MGC126849
基因别名: CER2; CERL2; CKTSF1B3; COCO; CRL2; DAND5; DANTE; GREM3; SP1
UniProt ID: (Human) Q8N907
Entrez Gene ID: (Human) 199699
determination of left/right asymmetry in lateral mesoderm
ventricular septum development
atrial septum development
signal transduction involved in regulation of gene expression
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
sequestering of BMP in extracellular matrix
sequestering of nodal from receptor via nodal binding
determination of heart left/right asymmetry
negative regulation of nodal signaling pathway
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
