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产品信息
PA5-89139
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-104 of human DBI (NP_001171513.1).
偶联物
形式
Liquid
浓度
0.84 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805381
产品详细信息
Immunogen sequence: MWGDLWLLPP ASANPGTGTE AEFEKAAEEV RHLKTKPSDE EMLFIYGHYK QATVGDINTE RPGMLDFTGK AKWDAWNELK GTSKEDAMKA YINKVEELKK KYGI; Positive Samples: HT-29, THP-1, MCF-7, NCI-H460, A673, U-937; Cellular Location: Endoplasmic reticulum, Golgi apparatus
靶标信息
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACBD 1; ACBP; acyl coenzyme A binding protein; acyl-CoA binding protein; Acyl-CoA-binding protein; acyl-Coenzyme A binding domain containing 1; CCK RP; CCKRP; cholecystokinin-releasing peptide, trypsin-sensitive; DBI; Diazepam binding inhibitor (GABA receptor modulator acyl-Coenxyme A binding protein); diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein); Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenxyme A binding protein); diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein); diazepam binding inhibitor, splice form 1b; Diazepam-binding inhibitor; Endozepine; EP; GABA receptor modulator; LRRGT00046; MGC70414; octadecaneuropeptide; triakontatetraneuropeptide; valium
基因别名: ACBD1; ACBP; Acoabp3; CCK-RP; DBI; endozepine; EP; Odn; RNACOABP3; Ttn
UniProt ID: (Human) P07108, (Mouse) P31786, (Rat) P11030
Entrez Gene ID: (Human) 1622, (Mouse) 13167, (Rat) 25045
transport
protein palmitoylation
phosphatidylcholine acyl-chain remodeling
behavioral fear response
hair follicle development
triglyceride metabolic process
learning or memory
glial cell proliferation
lateral ventricle development
negative regulation of fatty acid beta-oxidation
regulation of synaptic transmission, GABAergic
skin development
positive regulation of lipid biosynthetic process
positive regulation of release of sequestered calcium ion into cytosol
long-term synaptic potentiation
acyl-CoA metabolic process
steroid biosynthetic process
brain development
pancreatic juice secretion
cellular response to nutrient
