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DCPS Antibody (A305-426A) in IP
Detection of human DCPS by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-DCPS antibody (Product # A305-426A) (lot 1) used for IP at 6 µg per reaction. DCPS was also immunoprecipitated by rabbit anti-DCPS antibody A305-444A. For blotting immunoprecipitated DCPS, A305-426A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 10 seconds.
产品信息
A305-426A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 1 to 50 of human Scavenger mRNA-decapping enzyme DcpS.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase; DCS-1; Decapping scavenger enzyme; heat shock-like protein 1; HINT-5; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; homolog of C. elegans 7meGMP-directed hydrolase dcs-1; m7GpppX diphosphatase; mRNA decapping enzyme; Scavenger mRNA-decapping enzyme DcpS
基因别名: ARS; DCPS; DCS1; HINT-5; HINT5; HSL1; HSPC015
UniProt ID: (Human) Q96C86
Entrez Gene ID: (Human) 28960
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
deadenylation-dependent decapping of nuclear-transcribed mRNA
cellular response to menadione
negative regulation of programmed cell death
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
mRNA cis splicing, via spliceosome
RNA phosphodiester bond hydrolysis, exonucleolytic
