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产品信息
PA1-16598
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Hamster,
Human,
Mouse
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the C-terminal residues 200-251 of human Derlin-1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.1% sodium azide
保存条件
4° C, do not freeze
运输条件
Wet ice
RRID
AB_2230554
产品详细信息
This antibody is predicted to react with xenopus, bovine, chicken, rat, zebrafish, and mouse based on 100% sequence homology.
Suggested positive control: antigen standard for DERL1 (transient overexpression lysate), KRM (canine microsome) lysates.
靶标信息
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Degradation in endoplasmic reticulum protein 1; Der1-like domain family, member 1; Der1-like protein 1; derlin 1; Derlin-1; DERtrin-1
基因别名: 1110021N07Rik; AI195141; AW551338; DER-1; DER1; DERL1; Derlin-1; UNQ243/PRO276
UniProt ID: (Human) Q9BUN8, (Mouse) Q99J56
Entrez Gene ID: (Dog) 475086, (Human) 79139, (Mouse) 67819, (Chinese hamster) 103158862
response to unfolded protein
intracellular transport of viral protein in host cell
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
positive regulation of protein ubiquitination
protein destabilization
positive regulation of protein binding
ERAD pathway
establishment of protein localization
protein homooligomerization
ER-associated misfolded protein catabolic process
transport
protein transport
cellular response to unfolded protein
