Invitrogen

DERL1 Polyclonal Antibody

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DERL1 Antibody (PA5-97095) in WB

Western blot analysis of DERL1 in extracts of various cell lines. Samples were incubated with DERL1 Polyclonal antibody (Product # PA5-97095) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

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产品信息

PA5-97095

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:2,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 182-251 of human DERL1 (NP_0772711)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.95 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2808897

产品详细信息

Immunogen sequence: LYFFLMFRYP MDLGGRNFLS TPQFLYRWLP SRRGGVSGFG VPPASMRRAA DQNGGGGRHN WGQGFRLGDQ; Positive Samples: MCF-7, Mouse liver; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein

靶标信息

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。