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产品信息
PA5-18667
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (KLEHPTQQDIDLYH) corresponding to the internal amino acids of DGAT2 (aa 346-360).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10983983
产品详细信息
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
靶标信息
Acyl-coenzyme A:diacylglycerol acyltransferase, also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism, such as intestinal fat absorption, lipoprotein assembly, adipose tissue form-ation and lactation. DGAT2, which has no homology to DGAT1, differs from DGAT1 in that its activity has been shown to be inhibited by MgCl in an in vitro assay. DGAT2 is expressed primarily in liver and white adipose tissue, which suggests that it plays an important role in mammalian triglyceride metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Diacylglycerol O-acyltransferase 2; diacylglycerol O-acyltransferase homolog 2; diacylglycerol O-acyltransferase-like protein 2; Diglyceride acyltransferase 2; DKFZp686A15125
基因别名: ARAT; DGAT2; GS1999FULL; HMFN1045; UNQ738/PRO1433
UniProt ID: (Human) Q96PD7
Entrez Gene ID: (Human) 84649
glycerol metabolic process
positive regulation of triglyceride biosynthetic process
triglyceride biosynthetic process
lipid storage
low-density lipoprotein particle clearance
long-chain fatty-acyl-CoA metabolic process
cellular triglyceride homeostasis
acylglycerol acyl-chain remodeling
retinol metabolic process
cholesterol homeostasis
positive regulation of gluconeogenesis
negative regulation of fatty acid oxidation
diacylglycerol metabolic process
regulation of lipoprotein metabolic process
fatty acid homeostasis
fat pad development
cellular response to oleic acid
regulation of cholesterol metabolic process
regulation of plasma lipoprotein particle levels
