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产品信息
PA5-28495
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 1 and 161 of Human Smac
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545971
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse testis.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Diablo homolog, mitochondrial; Diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; Direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Second mitochondria-derived activator of caspases; SMAC; Smac protein; SMAC3
基因别名: 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; SMAC
UniProt ID: (Human) Q9NR28, (Mouse) Q9JIQ3
Entrez Gene ID: (Human) 56616, (Mouse) 66593
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
intrinsic apoptotic signaling pathway in response to oxidative stress
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
positive regulation of apoptotic process
neuron apoptotic process
intrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
