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产品信息
PA5-96420
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1149-1263 of human DIAPH1 (NP_0010732801)
偶联物
形式
Liquid
浓度
0.66 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808222
产品详细信息
Immunogen sequence: TEEKMRRAKL AKEKAEKERL EKQQKREQLI DMNAEGDETG VMDSLLEALQ SGAAFRRKRG PRQANRKAGC AVTSLLASEL TKDDAMAAVP AKVSKNSETF PTILEEAKEL VGRAS; Positive Samples: HL-60, MCF7, 293T, HepG2, Mouse liver, Mouse lung; Cellular Location: Cell membrane, Cell projection, Cytoplasm, cytoskeleton, ruffle membrane
靶标信息
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: diaphanous 1; diaphanous-1; diaphanous-related formin 1; Diaphanous-related formin-1; DRF1; FLJ25265; mDIA1; p140DIA; p140mDIA; Protein diaphanous homolog 1
基因别名: D18Wsu154e; DFNA1; DIA1; DIAP1; DIAPH1; DRF1; hDIA1; LFHL1; p140mDia; SCBMS
UniProt ID: (Human) O60610, (Mouse) O08808
Entrez Gene ID: (Human) 1729, (Mouse) 13367
cytoskeleton organization
sensory perception of sound
regulation of cell shape
actin filament polymerization
positive regulation of cell migration
regulation of microtubule-based process
protein localization to microtubule
regulation of release of sequestered calcium ion into cytosol
cellular response to histamine
regulation of cell motility
