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DIO3 Antibody (PA5-26537) in IHC (P)
Immunohistochemistry analysis of DIO3 in formalin-fixed and paraffin-embedded human hepatocarcinoma. Samples were incubated with DIO3 polyclonal antibody (Product # PA5-26537) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
产品信息
PA5-26537
产品规格
种属反应
Human,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human DIO3
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2544037
靶标信息
DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 5DIII; deiodinase, iodothyronine, type 3; DIOIII; iodothyronine deiodinase, placental type; Thyroxine 5-deiodinase; thyroxine deiodinase; thyroxine deiodinase type III (selenoprotein); Type 3 DI; type 3 iodothyronine selenodeiodinase; Type III iodothyronine deiodinase; type-III 5' deiodinase; type-III 5'-deiodinase
基因别名: 5DIII; D3; DIO3; DIOIII; ITDI3; TXDI3
UniProt ID: (Human) P55073, (Rat) P49897
Entrez Gene ID: (Human) 1735, (Rat) 29475
