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The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: dispatched A; dispatched homolog 1; DKFZP434I0428; FLJ43740; Mdispa; MGC104180; MGC13130; MGC16796; Protein dispatched homolog 1; twelve-pass transmembrane protein
基因别名: 1190008H24Rik; Disp; DISP1; DISPA; Icb; Icbins
UniProt ID: (Human) Q9H698, (Mouse) Q3TDN0
Entrez Gene ID: (Human) 84976, (Mouse) 68897